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Delta-protocadherins in health and disease.
A novel gene family NBPF: intricate structure generated by gene duplications during primate evolution.
- K. Vandepoele, N. Van Roy, K. Staes, F. Speleman, F. van Roy
- BiologyMolecular biology and evolution
- 1 November 2005
A novel and intricate human gene family located primarily in regions of segmental duplications on human chromosome 1 is identified, named NBPF, for neuroblastoma breakpoint family, because one of its members is disrupted by a chromosomal translocation in a Neuroblastoma patient.
A Constitutional Translocation t(1;17)(p36.2;q11.2) in a Neuroblastoma Patient Disrupts the Human NBPF1 and ACCN1 Genes
Cl cloning of both translocation breakpoints and the identification of a novel gene that is disrupted by this translocation are reported, indicating a role for the NBPF genes and for ACCN1 in tumor aggressiveness.
NBPF1, a tumor suppressor candidate in neuroblastoma, exerts growth inhibitory effects by inducing a G1 cell cycle arrest
It is shown that NBPF is expressed in the non-proliferative suprabasal layers of squamous stratified epithelia of human skin and cervix and exerted different tumor suppressive effects, depending on the cell line analyzed, and provide new clues into the molecular mechanism of the enigmatic NBPf proteins.
The NBPF1 promoter has been recruited from the unrelated EVI5 gene before simian radiation.
The recent acquisition of the NBPF1 promoter from an unrelated gene is described, and remarkably, both the donor and acceptor genes are disrupted by constitutional translocations in patients with neuroblastoma, suggesting a functional link between these genes and the disease.
Protocadherin-1 binds to SMAD3 and suppresses TGF-β1-induced gene transcription.
- Grissel Faura Tellez, K. Vandepoele, M. Nawijn
- Biology, MedicineAmerican journal of physiology. Lung cellular and…
- 1 October 2015
It is proposed that PCDH1 binds to SMAD3 and regulates its activation by TGF-β signaling in bronchial epithelial cells, which affects sensitivity of the airway epithelium to T GF-β.
Chibby interacts with NBPF1 and clusterin, two candidate tumor suppressors linked to neuroblastoma.
Standardization of Somatic Variant Classifications in Solid and Haematological Tumours by a Two-Level Approach of Biological and Clinical Classes: An Initiative of the Belgian ComPerMed Expert Panel
The ComPerMed workflow is described, which is a uniform, two-level classification workflow system that should enable high consistency in diagnosis, prognosis, treatment and follow-up of cancer patients and can be implemented in variant classification software tools enabling automatic reporting of NGS data.
Clinical implications of measurable residual disease in AML: Review of current evidence.
TARP is an immunotherapeutic target in acute myeloid leukemia expressed in the leukemic stem cell compartment
It is shown that the T-cell receptor γ chain alternate reading frame protein (TARP) is over-expressed in de novo pediatric and adult AML sorted leukemic stem cells and blasts compared to hematopoieticstem cells and normal myeloblasts.