K. Vávrová

Publications136
h-index31
Citations2,945
Highly Influential Citations38
Claim Author Page
Author pages are created from data sourced from our academic publisher partnerships and public sources.

Recommended Authors

  • P. Elias
  • 750 Publications • 51,856 Citations
  • J. Bouwstra
  • 432 Publications • 21,639 Citations
  • D. Richardson
  • 507 Publications • 27,983 Citations
  • G. Gooris
  • 119 Publications • 7,389 Citations
  • Publications
  • Influence
Amphiphilic transdermal permeation enhancers: structure-activity relationships.
TLDR
An overview of the methods used for investigation of the mechanisms of permeation enhancement, namely differential scanning calorimetry (DSC), infrared (IR) and Raman spectroscopy, X-ray diffraction and future perspectives in this field are given.
Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules.
TLDR
HA hydrogels restricted the delivery of biomacromolecules to the stratum corneum and viable epidermis in barrier deficient skin, and therefore seem to be potential topical drug vehicles.
Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.
TLDR
Results of the present study indicate that small, lipophilic and iron-specific chelators L1 and ICL670A can provide significant protection against the oxidative stress and cardiomyocyte damage exerted by catecholamines and/or their reactive oxidation intermediates.
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
TLDR
Interestingly, T SLP directly stimulated T cell migration exclusively in filaggrin-deficient skin equivalents even in the absence of dendritic cells, indicating a hitherto unknown role of TSLP in the pathogenesis of AD.
Dimethylamino Acid Esters as Biodegradable and Reversible Transdermal Permeation Enhancers: Effects of Linking Chain Length, Chirality and Polyfluorination
TLDR
DDAK, highly effective, broad-spectrum, biodegradable and reversible transdermal permeation enhancer, is promising candidate for future research.
Permeation enhancer dodecyl 6-(dimethylamino)hexanoate increases transdermal and topical delivery of adefovir: influence of pH, ion-pairing and skin species.
TLDR
The effect of permeation enhancer DDAK (6-dimethylaminohexanoic acid dodecyl ester) on the transdermal and topical delivery of adefovir and other acyclic nucleoside phosphonates offers an attractive alternative to established routes of administration.
S-substituted 3,5-dinitrophenyl 1,3,4-oxadiazole-2-thiols and tetrazole-5-thiols as highly efficient antitubercular agents.
TLDR
The analogues with a trifluoromethyl group instead of one of the nitro groups maintained a high antimycobacterial activity, which indicates the possibility for further structural optimization of this class of antitubercular agents.
Ceramides in the skin lipid membranes: length matters.
TLDR
The model skin lipid membranes are a valuable tool to study the relationships between the lipid structure and composition, lipid organization, and the membrane permeability, and long acyl chains in ceramides are essential for the formation of tightly packed impermeable lipid lamellae.
Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer
TLDR
The combined chemoimmunotherapy with DCVAC/PCa and docetaxel was safe and resulted in longer than expected survival and any immunological parameter was not identified that significantly correlated with better OS.
New fluorine-containing hydrazones active against MDR-tuberculosis.
TLDR
Several new fluorine-containing hydrazones were synthesized and screened for their in vitro antimycobacterial activity and all evaluated compounds were found to be non-cytotoxic.
...
1
2
3
4
5
...