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- Publications
- Influence
Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules.
- M. Witting, A. Boreham, +4 authors S. Hedtrich
- Chemistry, Medicine
- Molecular pharmaceutics
- 22 April 2015
Hyaluronic acid (HA) hydrogels are interesting delivery systems for topical applications. Besides moisturizing the skin and improving wound healing, HA facilitates topical drug absorption and is… Expand
Amphiphilic transdermal permeation enhancers: structure-activity relationships.
- K. Vávrová, J. Zbytovská, A. Hrabálek
- Chemistry, Medicine
- Current medicinal chemistry
- 31 August 2005
Transdermal drug delivery offers numerous advantages over conventional routes of administration; however, poor permeation of most drugs across the skin barrier constitutes a serious limitation of… Expand
Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.
- P. Hašková, L. Koubková, +5 authors T. Šimůnek
- Chemistry, Medicine
- Toxicology
- 18 November 2011
Catecholamines are stress hormones and sympathetic neurotransmitters essential for control of cardiac function and metabolism. However, pathologically increased catecholamine levels may be… Expand
Dimethylamino Acid Esters as Biodegradable and Reversible Transdermal Permeation Enhancers: Effects of Linking Chain Length, Chirality and Polyfluorination
- J. Novotny, P. Kováříková, M. Novotný, B. Janůšová, A. Hrabálek, K. Vávrová
- Chemistry, Medicine
- Pharmaceutical Research
- 1 April 2009
PurposeSeries of N,N-dimethylamino acid esters was synthesized to study their transdermal permeation-enhancing potency, biodegradability and reversibility of action. Effects of chirality, linking… Expand
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
- L. Wallmeyer, K. Dietert, +4 authors S. Hedtrich
- Medicine
- Scientific Reports
- 4 April 2017
Mutations in the gene encoding for filaggrin (FLG) are major predisposing factors for atopic dermatitis (AD). Besides genetic predisposition, immunological dysregulations considerably contribute to… Expand
Filaggrin deficiency leads to impaired lipid profile and altered acidification pathways in a 3D skin construct.
- K. Vávrová, Dominika Henkes, +9 authors S. Küchler
- Biology, Medicine
- The Journal of investigative dermatology
- 1 March 2014
Mutations in the filaggrin (FLG) gene are strongly associated with common dermatological disorders such as atopic dermatitis. However, the exact underlying pathomechanism is still ambiguous. Here, we… Expand
Comparison of clinically used and experimental iron chelators for protection against oxidative stress-induced cellular injury.
- P. Bendová, Eliška Macková, +9 authors T. Šimůnek
- Chemistry, Medicine
- Chemical research in toxicology
- 3 June 2010
Iron imbalance plays an important role in oxidative stress associated with numerous pathological conditions. Therefore, iron chelation may be an effective therapeutic approach, but progress in this… Expand
Ceramides in the skin lipid membranes: length matters.
- Barbora Školová, B. Janůšová, +8 authors K. Vávrová
- Chemistry, Medicine
- Langmuir : the ACS journal of surfaces and…
- 6 December 2013
Ceramides are essential constituents of the skin barrier that allow humans to live on dry land. Reduced levels of ceramides have been associated with skin diseases, e.g., atopic dermatitis. However,… Expand
Short-Chain Ceramides Decrease Skin Barrier Properties
- J. Novotný, B. Janůšová, M. Novotny, A. Hrabálek, K. Vávrová
- Chemistry, Medicine
- Skin Pharmacology and Physiology
- 2008
Stratum corneum ceramides are major determinants of skin barrier function. Although their physiological and pathological role has been widely investigated, to date no structure-activity relationships… Expand
Effect of ceramide acyl chain length on skin permeability and thermotropic phase behavior of model stratum corneum lipid membranes.
- B. Janůšová, J. Zbytovská, +4 authors K. Vávrová
- Chemistry, Medicine
- Biochimica et biophysica acta
- 1 March 2011
Stratum corneum ceramides play an essential role in the barrier properties of skin. However, their structure-activity relationships are poorly understood. We investigated the effects of acyl chain… Expand