Interactions of hyaluronic Acid with the skin and implications for the dermal delivery of biomacromolecules.
- M. Witting, A. Boreham, S. Hedtrich
- BiologyMolecular Pharmaceutics
- 22 April 2015
HA hydrogels restricted the delivery of biomacromolecules to the stratum corneum and viable epidermis in barrier deficient skin, and therefore seem to be potential topical drug vehicles.
TSLP is a direct trigger for T cell migration in filaggrin-deficient skin equivalents
- L. Wallmeyer, K. Dietert, S. Hedtrich
- Biology, MedicineScientific Reports
- 4 April 2017
Interestingly, T SLP directly stimulated T cell migration exclusively in filaggrin-deficient skin equivalents even in the absence of dendritic cells, indicating a hitherto unknown role of TSLP in the pathogenesis of AD.
Permeation enhancers in transdermal drug delivery: benefits and limitations
- A. Kováčik, Monika Kopečná, K. Vávrová
- Biology, ChemistryExpert Opinion on Drug Delivery
- 7 January 2020
This review focuses on permeation enhancers, which are chemicals that increase drug flux through the skin barrier, which suggest that enhancer-aided transdermal drug delivery has yet to reach its full potential.
Amphiphilic transdermal permeation enhancers: structure-activity relationships.
- K. Vávrová, J. Zbytovská, A. Hrabálek
- ChemistryCurrent Medicinal Chemistry
- 31 August 2005
An overview of the methods used for investigation of the mechanisms of permeation enhancement, namely differential scanning calorimetry (DSC), infrared (IR) and Raman spectroscopy, X-ray diffraction and future perspectives in this field are given.
Impact of intercellular crosstalk between epidermal keratinocytes and dermal fibroblasts on skin homeostasis.
- M. Jevtić, A. Löwa, S. Hedtrich
- Medicine, BiologyBiochimica et biophysica acta. Molecular cell…
- 14 April 2020
Phase I/II clinical trial of dendritic-cell based immunotherapy (DCVAC/PCa) combined with chemotherapy in patients with metastatic, castration-resistant prostate cancer
- M. Podrazil, R. Horváth, J. Fucikova
- Medicine, BiologyOncoTarget
- 28 May 2015
The combined chemoimmunotherapy with DCVAC/PCa and docetaxel was safe and resulted in longer than expected survival and any immunological parameter was not identified that significantly correlated with better OS.
Comparison of various iron chelators used in clinical practice as protecting agents against catecholamine-induced oxidative injury and cardiotoxicity.
- P. Hašková, L. Koubková, T. Šimůnek
- Biology, ChemistryToxicology
- 18 November 2011
Phase I/II trial of dendritic cell-based active cellular immunotherapy with DCVAC/PCa in patients with rising PSA after primary prostatectomy or salvage radiotherapy for the treatment of prostate…
- J. Fucikova, M. Podrazil, J. Bartunkova
- MedicineCancer Immunology and Immunotherapy
- 2017
Long-term immunotherapy of prostate cancer patients experiencing early signs of PSA recurrence using DCVAC/PCa was safe, induced an immune response and led to the significant prolongation of PSADT.
Dimethylamino Acid Esters as Biodegradable and Reversible Transdermal Permeation Enhancers: Effects of Linking Chain Length, Chirality and Polyfluorination
- J. Novotný, P. Kovaříková, M. Novotný, B. Janůšová, A. Hrabálek, K. Vávrová
- Chemistry, BiologyPharmaceutical Research
- 1 April 2009
DDAK, highly effective, broad-spectrum, biodegradable and reversible transdermal permeation enhancer, is promising candidate for future research.
Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β-D-ribofuranose 2'-Oxidase.
- Galina Karabanovich, J. Dušek, J. Roh
- Biology, ChemistryJournal of Medicinal Chemistry
- 8 August 2019
Almost all compounds with excellent antimycobacterial activities exhibited very low in vitro cytotoxicities against two proliferating mammalian cell lines, and the docking study indicated that these compounds acted as the inhibitors of decaprenylphosphoryl-β-D-ribofuranose 2'-oxidase (DprE1) enzyme.
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