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Tumour exosome integrins determine organotropic metastasis
TLDR
It is demonstrated that exosomes from mouse and human lung-, liver- and brain-tropic tumour cells fuse preferentially with resident cells at their predicted destination, namely lung fibroblasts and epithelial cells, liver Kupffer cells and brain endothelial cells.
View on Nature
Pattern of expression of the serotonin2C receptor messenger RNA in the basal ganglia of adult rats
TLDR
The data suggest that drugs acting on the 5‐HT2C receptor could selectively affect discrete neuronal populations in the basal ganglia and mesolimbic systems and indicate a new level of neurochemical heterogeneity among GABAergic neurons of the substantia nigra.
View on Wiley
Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells.
View on PubMed
Repetitive Mild Brain Trauma Accelerates Aβ Deposition, Lipid Peroxidation, and Cognitive Impairment in a Transgenic Mouse Model of Alzheimer Amyloidosis
TLDR
This is the first experimental evidence linking TBI to mechanisms of AD by showing that repetitive TBI accelerates brain Aβ accumulation and oxidative stress, which it is suggested could work synergistically to promote the onset or drive the progression of AD.
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Increased Lipid Peroxidation Precedes Amyloid Plaque Formation in an Animal Model of Alzheimer Amyloidosis
TLDR
Because LPO precedes amyloid plaque formation in Tg2576 mice, this suggests that brain oxidative damage contributes to AD pathogenesis before Aβ accumulation in the AD brain.
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Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans
View on Elsevier
Pathological Axonal Death through a MAPK Cascade that Triggers a Local Energy Deficit
View on Elsevier
Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases
Here, we investigated if TAR-DNA-binding protein-43 (TDP-43), the disease protein in frontotemporal lobar degeneration and ubiquitin inclusions with or without motor neuron disease as well as…
View on Springer
Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury
View on Elsevier
Concomitant TAR-DNA-Binding Protein 43 Pathology Is Present in Alzheimer Disease and Corticobasal Degeneration but Not in Other Tauopathies
TLDR
Findings provide further insight into the burden and clinical significance of TDP-43 pathology in disorders other than FTLD-U and amyotrophic lateral sclerosis.
View on Wolters Kluwer
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