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A source of hydrogen sulfide and a mechanism of its release in the brain.
It is shown that H2S is released from bound sulfur, an intracellular store of sulfur, in neurons and astrocytes of mice and rats in the presence of physiologic concentrations of endogenous reducing substances glutathione and cysteine. Expand
Hydrogen Sulfide Is Produced in Response to Neuronal Excitation
It is shown that cystathionine β-synthase produces endogenous H2S in the brain and thatH2S production is greatly enhanced by the excitatory neurotransmitterl-glutamate, as well as by electrical stimulation, and that it may regulate some aspects of synaptic activity. Expand
Physiological roles of hydrogen sulfide: synaptic modulation, neuroprotection, and smooth muscle relaxation.
H(2)S, the toxic gas, may be used as a multifunctional signaling mechanism under normal physiological conditions and protects neurons from oxidative stress and in smooth muscle it may function as a relaxant. Expand
Preconditioning by sesquiterpene lactone enhances H2O2-induced Nrf2/ARE activation.
It is suggested that preconditioning by sesquiterpene lactone may enhance activation of the Nrf2/ARE pathway and induction of phase II detoxification/antioxidant enzymes upon oxidative stress, thereby resulting in increased resistance to oxidative damage. Expand
Leptosins M–N1, cytotoxic metabolites from a Leptosphaeria species separated from a marine alga. Structure determination and biological activities
Abstract Leptosins M ( 4 ), M1 ( 5 ) N ( 6 ) and N1 ( 7 ) have been isolated from a strain of Leptosphaeria sp. originally separated from the marine alga Sargassum tortile. Their absoluteExpand
Determination of oxidized and reduced nicotinamide adenine dinucleotide in cell monolayers using a single extraction procedure and a spectrophotometric assay.
A novel method to measure NAD+ and NADH in monolayers of a neuroblastoma cell line by modifying a single extraction procedure originally developed for erythrocytes and an enzymatic cycling assay using a dye that absorbs in visible range is shown. Expand
Inhibition of DNA topoisomerases II and/or I by pyrazolo[1,5-a]indole derivatives and their growth inhibitory activities.
DNA topoisomerases (topos) I and II are molecular targets of several potent anticancer agents. Thus inhibitors of these enzymes are potential candidates or model compounds for anticancer drugs. WeExpand
Autotaxin expression is enhanced in frontal cortex of Alzheimer-type dementia patients
Observations suggest that expression of the autotaxin gene and cell signaling by lysophosphatidic acid may be involved in the pathology of ATD, and that this cell signaling pathway may be a potential target of treatments for ATD. Expand
Sirtuin 1 overexpression mice show a reference memory deficit, but not neuroprotection.
Overexpression of SIRT1 did not have any neuroprotective effects against the neuronal damage induced by ischemia or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, and these findings suggest that an excessive expression of Sirt1 might induce the memory deficit in mice, but not neuroprot protective effects. Expand