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Soy isoflavones lower serum total and LDL cholesterol in humans: a meta-analysis of 11 randomized controlled trials.
- Kyoko Taku, K. Umegaki, Y. Sato, Yuko Taki, K. Endoh, S. Watanabe
- The American journal of clinical nutrition
- 1 April 2007
BACKGROUND Clinical trials have reported the cholesterol-lowering effects of soy protein intake, but the components responsible are not known. OBJECTIVE This meta-analysis was primarily conducted… Expand
Relationship between dietary folate intakes, maternal plasma total homocysteine and B-vitamins during pregnancy and fetal growth in Japan
BackgroundAdequate folate status in pregnancy is important for satisfactory pregnancy outcome.Aim of the StudyThe objective of the present study was to evaluate folate status in healthy pregnant… Expand
Ginkgo biloba extract markedly induces pentoxyresorufin O-dealkylase activity in rats.
- K. Umegaki, Keiko Saito, Y. Kubota, H. Sanada, K. Yamada, K. Shinozuka
- Chemistry, Medicine
- Japanese journal of pharmacology
- 1 December 2002
We examined the effect of Ginkgo biloba extract (GBE) on hepatic drug-metabolizing enzymes, particularly cytochrome P450 (CYP), in rats. Rats were fed a GBE-containing diet or received GBE by… Expand
Health claim evidence requirements in Japan.
In the early 1980s the Japanese scientific academy defined a functional food as a food having a tertiary or physiologically active function. The current Japanese "Food with Health Claims" include 2… Expand
Tea catechins prevent the development of atherosclerosis in apoprotein E-deficient mice.
Green tea contains various antioxidative flavan-3ols (tea catechins), such as (-)-epigallocatechin gallate (EGCg, the major catechin), which exert potent inhibitory effects on LDL oxidation in vitro… Expand
Effects of Ginkgo Biloba Extract on Pharmacokinetics and Pharmacodynamics of Tolbutamide and Midazolam in Healthy Volunteers
This study was undertaken to clarify the influence of repeated oral administration of Ginkgo biloba extract (GBE) on CYP2C9 and CYP3A4. CYP2C9 probe (tolbutamide, 125 mg) and CYP3A4 probe (midazolam,… Expand
Methylenetetrahydrofolate reductase C677T polymorphism, folic acid and riboflavin are important determinants of genome stability in cultured human lymphocytes.
- Michiyo Kimura, K. Umegaki, M. Higuchi, P. Thomas, M. Fenech
- Biology, Medicine
- The Journal of nutrition
We tested the hypothesis that methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism, folic acid deficiency and riboflavin deficiency, independently or interactively, are important… Expand
Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats.
Ginkgo biloba extract (GBE) has been used clinically for improving peripheral vascular diseases in France and Germany and is ingested widely as a herbal medicine in some countries. However, accurate… Expand
Physiological concentrations of (-)-epigallocatechin-3-O-gallate (EGCg) prevent chromosomal damage induced by reactive oxygen species in WIL2-NS cells.
We investigated the effects of (-)-epigallocatechin-3-O-gallate (EGCg) on chromosomal damage, which was evaluated by a cytokinesis-block micronucleus (CBMN) assay using WIL2-NS cells. EGCg itself… Expand
Influence of one bout of intensive running on lymphocyte micronucleus frequencies in endurance-trained and untrained men.
- K. Umegaki, M. Higuchi, K. Inoue, T. Esashi
- International journal of sports medicine
- 1 November 1998
Exercise induced chromosomal damage was evaluated in trained and untrained subjects, who performed treadmill running at 85% of maximal oxygen uptake for 30 min. The subjects had their peripheral… Expand