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Identification and characterization of a gonadotropin-inhibitory system in the brains of mammals
TLDR
The distribution of GnIH efferents to neural sites regulating reproductive behavior and neuroendocrine secretions, expression of steroid receptors in GnIh-ir nuclei, and GnI H inhibition of luteinizing hormone secretion indicate the discovery of a system regulating the mammalian reproductive axis.
A novel avian hypothalamic peptide inhibiting gonadotropin release.
TLDR
It is shown, in a bird, that the hypothalamus also contains a novel peptide which inhibits gonadotropin release, the first hypothalamic peptide inhibiting gonadotropic hormone reported in a vertebrate.
Identification, expression, and physiological functions of Siberian hamster gonadotropin-inhibitory hormone.
TLDR
The results suggest that GnIH peptides fine tune LH levels via its receptor expressed in GnRH-ir neurons in an opposing fashion across the seasons in Siberian hamsters.
Melatonin induces the expression of gonadotropin-inhibitory hormone in the avian brain.
TLDR
It is shown that melatonin originating from the pineal gland and eyes induces GnIH expression in the quail brain, the first demonstration, to the authors' knowledge, of a direct action of melatonin on neuropeptide induction in any vertebrate class.
Gonadotropin-inhibitory hormone in Gambel's white-crowned sparrow (Zonotrichia leucophrys gambelii): cDNA identification, transcript localization and functional effects in laboratory and field
TLDR
Results indicate that, despite amino acid sequence differences, quail GnIH and sparrow GnIh have similar inhibitory effects on the reproductive axis in wild sparrow species, and GniH appears to be a modulator of gonadotropin release.
Isolation and characterization of a GnRH-like peptide from Octopus vulgaris.
TLDR
An octopus peptide with structural features similar to vertebrate GnRHs was isolated from brains of Octopus vulgaris and showed luteinizing hormone-releasing activity in quail anterior pituitary cells.
Gonadotropin‐Inhibitory Peptide in Song Sparrows (Melospiza melodia) in Different Reproductive Conditions, and in House Sparrows (Passer domesticus) Relative to Chicken‐Gonadotropin‐Releasing Hormone
TLDR
GnIH has the potential to regulate gonadotropin release at more than one level, and its distribution is suggestive of multiple regulatory functions in the central nervous system.
A novel G protein-coupled receptor for gonadotropin-inhibitory hormone in the Japanese quail (Coturnix japonica): identification, expression and binding activity.
TLDR
Southern blotting analysis of reverse transcriptase-mediated PCR products revealed the expression of GnIH receptor mRNA in the pituitary gland and several brain regions including diencephalon in the quail, suggesting that GnIh acts directly on thepituitary via GnI H receptor to inhibit gonadotropin release.
Distribution of a novel avian gonadotropin-inhibitory hormone in the quail brain
TLDR
Quantitative analysis demonstrated that the concentration of GnIH in the diencephalon was greater than that in the mesencephalon without sex difference, suggesting that GnIIH may participate not only in neuroendocrine functions, but also in behavioral and autonomic mechanisms.
Gonadotropin-inhibitory hormone inhibits gonadal development and maintenance by decreasing gonadotropin synthesis and release in male quail.
TLDR
GnIH is the first identified hypothalamic neuropeptide inhibiting reproductive function in any vertebrate class and may explain the phenomenon of photoperiod-induced gonadal regression before an observable decline in hypothalamic GnRH in quail.
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