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EP4 as a Therapeutic Target for Aggressive Human Breast Cancer
A case is made for EP4 as a promising newer therapeutic target for treating breast cancer, and it is suggested that EP4A will likely produce the highest benefit in aggressive breast cancers, when combined with other newer agents, such as inhibitors of programmed cell death (PD)-1 or PD-L1.
Mir526b and Mir655 Promote Tumour Associated Angiogenesis and Lymphangiogenesis in Breast Cancer
The roles of cyclo-oxygenase (COX)-2 induced miR526b and miR655 in tumour-associated angiogenesis and lymphangiogenesis are examined and EP4 is considered as a potential therapeutic target to abrogate miRNA-induced angiogenic and lymphangaogenesis in breast cancer.
miR526b and miR655 Induce Oxidative Stress in Breast Cancer
The dynamic functions of miR526b/miR655 in oxidative stress induction in breast cancer are established, and treatment with miRNA-conditioned media upregulates TXNRD1 in both MCF7 and HUVECs, indicating that oxidative stress also induces miRNA overexpression.
Prostaglandin E2 promotes embryonic vascular development and maturation in zebrafish
The novel roles of PGE2 in promoting embryonic vascular maturation and angiogenesis in zebrafish are shown, which causes inflammation and cancer and its blockage results in serious physiological consequences.
EP 4 as a Therapeutic Target for Aggressive Human Breast Cancer
G-protein-coupled receptors (GPCRs, also called seven-transmembrane or heptahelical receptors) are a superfamily of cell surface receptor proteins that bind to many extracellular ligands and transmit
Pri-miR526b and Pri-miR655 Are Potential Blood Biomarkers for Breast Cancer
It is reported for the first time that miRNA precursor RNAs (pri-miRNAs) are robust and sensitive biomarkers for BC, detectable in both human blood plasma and biopsy tissues, and pri-miRNA expression in independent tumor bank tissues is validated, showing significant upregulation of both pri- miRNAs in BC.
Total Energy Calculation of Alas and InAs Binary Semiconductors Using the Projector Augmented Wave Method
The total energy of an element is the basic energy value from which other properties of the element can be calculated. Aluminum Arsenide (AlAs) and Indium Arsenide (InAs) are III – Arsenic binary
First person – Kingsley Ugwuagbo and Sujit Maiti
ABSTRACT First Person is a series of interviews with the first authors of a selection of papers published in Biology Open, helping early-career researchers promote themselves alongside their papers.