• Publications
  • Influence
Cloning and Characterization of Two Extracellular Heparin-degrading Endosulfatases in Mice and Humans*
Here we report the cloning of a full-length cDNA encoding the human ortholog (HSulf-1) of the developmentally regulated putative sulfatases QSulf-1 (Dhoot, G. K., Gustafsson, M. K., Ai, X., Sun, W.,Expand
  • 361
  • 31
Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia.
The inducible isoform of the enzyme cyclooxygenase-2 (COX2) is an immediate early gene induced by synaptic activity in the brain. COX2 activity is an important mediator of inflammation, but it is notExpand
  • 319
  • 23
  • PDF
Minocycline selectively inhibits M1 polarization of microglia
Minocycline is commonly used to inhibit microglial activation. It is widely accepted that activated microglia exert dual functions, that is, pro-inflammatory (M1) and anti-inflammatory (M2)Expand
  • 361
  • 22
HSulf-2, an extracellular endoglucosamine-6-sulfatase, selectively mobilizes heparin-bound growth factors and chemokines: effects on VEGF, FGF-1, and SDF-1
BackgroundHeparin/heparan sulfate (HS) proteoglycans are found in the extracellular matrix (ECM) and on the cell surface. A considerable body of evidence has established that heparin and heparanExpand
  • 197
  • 13
Interaction of the selectin ligand PSGL-1 with chemokines CCL21 and CCL19 facilitates efficient homing of T cells to secondary lymphoid organs
P-selectin glycoprotein ligand 1 (PSGL-1) is central to the trafficking of immune effector cells to areas of inflammation through direct interactions with P-selectin, E-selectin and L-selectin. HereExpand
  • 109
  • 8
  • PDF
N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules
Lymphocyte homing is mediated by specific interactions between L-selectin on lymphocytes and sulfated carbohydrates restricted to high endothelial venules in lymph nodes. Here we generated miceExpand
  • 151
  • 7
A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules
The interaction of L-selectin on lymphocytes with sulfated ligands on high endothelial venules leads to rolling and is critical for recruitment of lymphocytes into peripheral lymph nodes. PeripheralExpand
  • 149
  • 7
  • PDF
Molecular cloning and expression of human chondroitin 6-sulfotransferase.
Using cDNA of chick chondroitin 6-sulfotransferase (C6ST), human C6ST cDNA has been isolated. The amino acid sequence of human C6ST displayed 74% identity to chick C6ST. The major difference in aminoExpand
  • 78
  • 7
Sulf-2, a proangiogenic heparan sulfate endosulfatase, is upregulated in breast cancer.
Sulf-2 is an endosulfatase with activity against glucosamine-6-sulfate modifications within subregions of intact heparin. The enzyme has the potential to modify the sulfation status of extracellularExpand
  • 133
  • 6
Molecular Cloning and Expression of Chick Chondrocyte Chondroitin 6-Sulfotransferase (*)
Chondroitin 6-sulfotransferase (C6ST) catalyzes the transfer of sulfate from 3′-phosphoadenosine 5′-phosphosulfate to position 6 of the N-acetylgalactosamine residue of chondroitin. The enzyme hasExpand
  • 110
  • 6