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Effects of Plasmodium berghei infection on arteether metabolism and disposition.
Arteether (AE) is primarily deethylated to dihydroqinghaosu (DQHS) in rats and humans. Conversion of AE to DQHS was impaired in microsomes from rats infected with Plasmodium berghei. The Km for AEExpand
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Mefloquine Effect on Disposition of Halofantrine in the Isolated Perfused Rat Liver
Halofantrine and mefloquine are antimalarial drugs used in the treatment of malaria, including that caused by chloroquine‐resistant Plasmodium falciparum. Reports of drug‐associated adverseExpand
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The in vitro metabolism of penclomedine in mouse, rat, and human systems.
Penclomedine is a multi-chlorinated alpha-picoline derivative that has demonstrated activity in several murine breast cancer models and is currently in clinical testing for use against solid tumors.Expand
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Rapid Derivatization of Alcohols with Carboxylic-Sulphonic Mixed Anhydrides for HPLC-UV/Fluorescence Analysis: Application to the Detection of Dihydroqinghaosu (DQHS) and its Metabolites in
Abstract The formation of ester derivatives of alcohols for the purpose of HPLC-ultraviolet/fluorescence analysis is achieved rapidly when a mixture of the alcohol and the triethylamine salt of theExpand
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A hazardous side effect of neuroleptics: diagnosis and treatment.
Neuroleptic malignant syndrome (NMS) is a potentially fatal disease process characterized by hyperthermia, altered mental status, muscular rigidity, and autonomic instability. This syndrome is mostExpand