• Publications
  • Influence
Monoclonal antibodies to reovirus reveal structure/function relationships between capsid proteins and genetics of susceptibility to antibody action
TLDR
Competition between MAbs revealed two surface epitopes on mu 1c that were highly conserved between reovirus serotype 1 Lang (T1L) and serotype 3 Dearing (T3D) and there were several differences between T1L and T3D sigma 3 epitope maps. Expand
Thymidine kinase-negative herpes simplex virus mutants establish latency in mouse trigeminal ganglia but do not reactivate.
TLDR
It is suggested that acyclovir-resistant viruses could establish latent infections in clinical settings and have implications for the use of genetically engineered herpesviruses to deliver foreign genes to neurons. Expand
Antibody protects against lethal infection with the neurally spreading reovirus type 3 (Dearing)
TLDR
Polyclonal and monoclonal antibodies protect mice from fatal infection with T3 after either footpad or intracerebral virus challenge and antibody mediated protection against this neurally spreading virus does not require neutralizing antibody or serum complement and occurs even in the face of established CNS infection. Expand
Herpes simplex virus infections of the central nervous system: encephalitis and meningitis, including Mollaret's.
  • K. Tyler
  • Medicine
  • Herpes : the journal of the IHMF
  • 1 June 2004
TLDR
Polymerase chain reaction (PCR) of the cerebrospinal fluid (CSF) is the diagnostic method of choice for HSE, but negative results need to be interpreted in the context of the patient's clinical presentation and the timing of the CSF sampling. Expand
Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis.
A 46-year-old woman with relapsing-remitting multiple sclerosis died from progressive multifocal leukoencephalopathy (PML) after having received 37 doses of natalizumab (300 mg every four weeks) asExpand
West Nile virus neuroinvasive disease
TLDR
Recent studies suggest that some WNV‐infected patients have persistent WNV IgM serum and/or cerebrospinal fluid antibody responses, and this may require revision of current serodiagnostic criteria. Expand
A randomized vehicle-controlled trial of topical capsaicin in the treatment of postherpetic neuralgia.
TLDR
It is concluded that capsaicin 0.075% cream is a safe and effective treatment for the pain of postherpetic neuralgia and should be considered for initial management of patients with this condition. Expand
HAART improves prognosis in HIV-associated progressive multifocal leukoencephalopathy
TLDR
It is concluded that current HIV therapy is important in improving the outlook of PML in the setting of HIV. Expand
Reovirus-Induced Apoptosis Is Mediated by TRAIL
TLDR
It is proposed that reovirus infection promotes apoptosis via the expression of DR5 and the release of TRAIL from infected cells and Virus-induced regulation of the TRAIL apoptotic pathway defines a novel mechanism for virus-induced apoptosis. Expand
Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis.
TLDR
These cases suggest an increased risk, about 1 case per 25 000 individuals, of PML in patients with RA being treated with rituximab, even while CD20 counts remain low. Expand
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