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Treatment-Emergent Influenza Variant Viruses With Reduced Baloxavir Susceptibility: Impact on Clinical and Virologic Outcomes in Uncomplicated Influenza.
BACKGROUND Single-dose baloxavir rapidly reduces influenza virus titers and symptoms in patients with uncomplicated influenza, but viruses with reduced in vitro susceptibility due to amino acidExpand
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Baloxavir Marboxil in Japanese Pediatric Patients With Influenza: Safety and Clinical and Virologic Outcomes
Abstract Background We assessed the safety and effectiveness of baloxavir marboxil administration in Japanese children with influenza. Methods This open-label study administered 1 weight-adjustedExpand
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Pre-discharge and flashover characteristics of impulse surface discharge in vacuum
Surface discharge on solid insulators is one of the significant issues in the development of vacuum circuit breakers (VCB) and vacuum interrupters (VI). We measured the charge activity on aluminaExpand
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Impulse surface flashover development associated with transient charging by explosive electron emission in vacuum
Surface discharge on solid insulator in vacuum, which is one of the most significant issues under high electric field, prevents the development of higher voltage vacuum circuit breakers and vacuumExpand
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Early treatment with baloxavir marboxil in high-risk adolescent and adult outpatients with uncomplicated influenza (CAPSTONE-2): a randomised, placebo-controlled, phase 3 trial.
BACKGROUND Baloxavir marboxil (hereafter baloxavir), a selective inhibitor of influenza cap-dependent endonuclease, was approved in 2018 in the USA and Japan for the treatment of uncomplicatedExpand
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Baloxavir Marboxil 2% Granules in Japanese Children With Influenza
Supplemental Digital Content is available in the text. Background: A granule formulation of baloxavir marboxil, a selective inhibitor of influenza cap-dependent endonuclease, was newly developed forExpand
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Control and suppression of impulse surface flashover in vacuum based on discharge development mechanisms
Surface discharge on solid insulator in vacuum is one of the significant issues for the development of vacuum circuit breakers (VCBs) and vacuum interrupters (VIs). For the development of higherExpand
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Application of E-beam recrystallization to three-layer image processor fabrication
E-beam recrystallization has been applied to the fabrication of a three-layer processor. The seed structure and the E-beam conditions were successfully optimized so that a large-area SOI as wide as 1Expand
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