Molecular genetic and chemical assessment of radix Angelica (Danggui) in China.
- K. Zhao, T. Dong, P. Tu, Zong H Song, C. Lo, K. Tsim
- Biology, MedicineJournal of Agricultural and Food Chemistry
- 27 March 2003
The roots of Angelica sinensis (Danggui), a traditional Chinese medicine, have been used for invigorating blood circulation for over 2000 years in China and could serve as a fingerprint for quality control ofangelica roots.
Chemical assessment of roots of Panax notoginseng in China: regional and seasonal variations in its active constituents.
Using the contents of these active constituents as markers, the best quality of Radix Notoginseng is found in the southwestern parts of Wenshan, and the best season for the harvest is September to October, while the unseeded plants produced a better quality.
A polysaccharide isolated from Cordyceps sinensis, a traditional Chinese medicine, protects PC12 cells against hydrogen peroxide-induced injury.
- Shao-Ping Li, K. Zhao, K. Tsim
- BiologyLife Science
- 26 September 2003
Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.
The current results support the ancient formulation of DBT, and several chemicals showed positive correlation with DBT-induced bioactivities and could serve as markers for quality control of D BT.
Quality evaluation of Rhizoma Belamcandae (Belamcanda chinensis (L.) DC.) by using high-performance liquid chromatography coupled with diode array detector and mass spectrometry.
In vitro estrogenic activity of formononetin by two bioassay systems
- Z. Ji, W. Y. Zhao, K. Tsim
- Biology, MedicineGynecological Endocrinology
- 1 January 2006
Formononetin is a phytoestrogen that exhibits variable degrees of estrogen receptor agonism in different test systems and it induced the proliferation of MCF-7 breast cancer cells and MG-63 osteosarcoma cells, and it also increased the alkaline phosphatase activity in MG- 63 cells.
Flavonoids possess neuroprotective effects on cultured pheochromocytoma PC12 cells: a comparison of different flavonoids in activating estrogenic effect and in preventing beta-amyloid-induced cell…
- Judy T. T. Zhu, R. Choi, K. Tsim
- BiologyJournal of Agricultural and Food Chemistry
- 27 February 2007
Among these flavonoids, baicalein, scutellarin, hibifolin, and quercetin-3'-glucoside possessed the strongest effect in neuroprotection; however, the neuroprotective activity did not directly correlate with the estrogenic activity of the flavonoid.
The Standardized Extract of Ziziphus jujuba Fruit (Jujube) Regulates Pro‐inflammatory Cytokine Expression in Cultured Murine Macrophages: Suppression of Lipopolysaccharide‐stimulated NF‐κB Activity
- Jianping Chen, C. Du, K. Tsim
- BiologyPhytotherapy Research
- 1 October 2014
Results verified the bidirectional immune‐modulatory roles of jujube by regulating the expressions of pro‐inflammatory cytokines in macrophages.
Orthogonal array design in optimizing the extraction efficiency of active constituents from roots of Panax notoginseng
- T. Dong, K. Zhao, W. Z. Huang, K. Leung, K. Tsim
- ChemistryPhytotherapy Research
- 1 August 2005
The activity of anti‐platelet aggregation was found to be the highest in the extract that contained a better yield of the active constituents, providing an optimized extraction method for the quality control of Radix Notoginseng.
Baicalin, a flavone, induces the differentiation of cultured osteoblasts: an action via the Wnt/β-catenin signaling pathway.
The total GSK-3 , or its phosphorylated form (P-GSK-3 ), was revealed (both at 46 kDa) by specific antibodies in Western blot (upper panel) and the quantification of the blots was performed by a densitometer (lower panel), which was quantified based on the four independent results, as shown here.