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Direct Inhibition of Mitochondrial Respiratory Chain Complex III by Cell-permeable Ceramide*
It is demonstrated that ceramide can directly inhibit mitochondrial respiratory chain function in isolated mitochondria, and suggested that these in vitro observations may set the stage for identifying a novel mechanism of regulation of mitochondrial function in vivo.
Differential effects of saturated and unsaturated fatty acid diets on cardiomyocyte apoptosis, adipose distribution, and serum leptin.
Dietary fatty acid composition affects cardiac ceramide accumulation, cardiomyocyte apoptosis, and expression of PPAR-regulated genes independent of cardiac mass or function.
Calcitroic acid, end product of renal metabolism of 1,25-dihydroxyvitamin D3 through C-24 oxidation pathway.
The metabolic fate of 1,25-dihydroxyvitamin D3 (3 X 10(-10) M) in the perfused rat kidney is investigated and calcitroic acid is identified as the major water-soluble metabolite of 2,000-day-old rat kidney.
An improved procedure for the synthesis of glycine and taurine conjugates of bile acids.
Glycine and taurine conjugates of 5beta-cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The…
Pharmacokinetics of O6‐Benzylguanine (NSC637037) and Its Metabolite, 8‐Oxo‐O6‐Benzylguanine
Metabolite kinetics are evaluated using both a novel approach describing the relationship between O6‐benzylguanine and 8‐oxo‐O 6‐benZylguAnine and classical metabolite Kinetics methods.
Abrin and Ricin: New Anti-tumour Substances
The inhibitory effect of abrin and ricin on Ehrlich ascites tumour has been demonstrated by simultaneous injection of a sublethal dose with the tumour cells, which indicates that the anti-tumour activity of phytotoxins is due to protein.
Metabolism of urea and glucose in normal and diabetic pregnancy.
Estimation of glucose carbon recycling and glucose turnover with [U-13C] glucose.
To estimate "true" rate of glucose production, as well as glucose carbon recycling in humans, a mass spectrometric method with [U-13C]glucose as tracer was developed, permits estimation of important parameters of glucose metabolism without resorting to multiple tracers and at the same time preventing the risk of radiation.
Effects of chronic activation of peroxisome proliferator-activated receptor-alpha or high-fat feeding in a rat infarct model of heart failure.
- Eric E Morgan, J. Rennison, M. Chandler
- Biology, MedicineAmerican journal of physiology. Heart and…
- 1 May 2006
In conclusion, LV dysfunction and dilation are not worsened despite upregulation of the fatty acid metabolic pathway and LV hypertrophy or accumulation of myocardial triglyceride in the rat infarct model of HF.