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Impaired endochondral ossification and angiogenesis in mice deficient in membrane-type matrix metalloproteinase I.
Membrane-type matrix metalloproteinase I (MT1-MMP)-deficient mice were found to have severe defects in skeletal development and angiogenesis. The craniofacial, axial, and appendicular skeletons wereExpand
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Metastatic potential correlates with enzymatic degradation of basement membrane collagen
Tumour cells traverse epithelial and endothelial basement membranes during the successive stages of the metastatic process. At the transition from in situ to invasive carcinoma, local dissolution ofExpand
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Alport's syndrome, Goodpasture's syndrome, and type IV collagen.
Defects in type IV collagen, a collagenous protein involved in the formation of basement membranes, have been implicated in hereditary Alport's syndrome and acquired Goodpasture's syndrome. MutationsExpand
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Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages
A novel murine plasma membrane protein has been identified in subpopulations of macrophages. It has an intracellular N-terminal domain, a transmembrane domain, and an extracellular region with aExpand
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The vascular basement membrane: a niche for insulin gene expression and Beta cell proliferation.
Endocrine pancreatic beta cells require endothelial signals for their differentiation and function. However, the molecular basis for such signals remains unknown. Here, we show that beta cells, inExpand
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MARCO, TLR2, and CD14 Are Required for Macrophage Cytokine Responses to Mycobacterial Trehalose Dimycolate and Mycobacterium tuberculosis
Virtually all of the elements of Mycobacterium tuberculosis (Mtb) pathogenesis, including pro-inflammatory cytokine production, granuloma formation, cachexia, and mortality, can be induced by itsExpand
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Genomic instability in laminopathy-based premature aging
Premature aging syndromes often result from mutations in nuclear proteins involved in the maintenance of genomic integrity. Lamin A is a major component of the nuclear lamina and nuclear skeleton.Expand
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Hereditary proteinuria syndromes and mechanisms of proteinuria.
This review summarizes recent advances in our knowledge of the glomerular filter and the causes of hereditary proteinuria syndromes.
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Accelerated ageing in mice deficient in Zmpste24 protease is linked to p53 signalling activation
Zmpste24 (also called FACE-1) is a metalloproteinase involved in the maturation of lamin A (Lmna), an essential component of the nuclear envelope. Both Zmpste24- and Lmna-deficient mice exhibitExpand
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Isolation and characterization of type IV procollagen, laminin, and heparan sulfate proteoglycan from the EHS sarcoma.
We have studied the extractability of type IV collagen, laminin, and heparan sulfate proteoglycan from EHS tumor tissue growth in normal and lathyritic animals. Laminin and heparan sulfateExpand
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