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Plasma viscosity: a forgotten variable.
In hyperviscosity syndromes plasma viscosity is better in follow-up than ESR, and in rheumatoid arthritis, its sensitivity and specificity are better than that of ESR or C-reactive protein.
Endoplasmic reticulum stress as a novel therapeutic target in heart diseases.
- Ambrus Tóth, Philip Nickson, Adel Mandl, M. Bannister, K. Toth, P. Erhardt
- BiologyCardiovascular & Haematological Disorders - Drug…
- 31 August 2007
The endoplasmic reticulum (ER) is a multifunctional organelle responsible for the synthesis and folding of proteins as well as calcium storage and signaling. Perturbations of ER function cause ER…
Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat.
Effect of poly(ADP-ribose) polymerase inhibitors on the ischemia-reperfusion-induced oxidative cell damage and mitochondrial metabolism in Langendorff heart perfusion system.
- R. Halmosi, Z. Berente, E. Ősz, K. Toth, P. Literati-Nagy, B. Sumegi
- BiologyMolecular pharmacology
- 1 June 2001
PARP inhibitors, in addition to their important primary effect of decreasing the activity of nuclear PARP and decreasing NAD(+) and ATP consumption, reduce ischemia-reperfusion-induced endogenous ROS production and protect the respiratory complexes from ROS induced inactivation, providing an additional mechanism by which they can protect heart from oxidative damages.
Clinical efficacy and safety of achieving very low LDL-cholesterol concentrations with the PCSK9 inhibitor evolocumab: a prespecified secondary analysis of the FOURIER trial
Glycoprotein IIIA Gene (PIA) Polymorphism and Aspirin Resistance: Is There Any Correlation?
The results support the hypothesis that carriers of the PIA2 allele might have an increased risk for acute coronary syndrome and suggest that patients with Pia2 allele homozygosity might benefit from antiplatelet therapy based on adenosine diphosphate antagonists throughout secondary treatment for prevention of ACS.
Prevention of Doxorubicin-Induced Acute Cardiotoxicity by an Experimental Antioxidant Compound
It is proposed that the coadministration of the antioxidant H-2545 attenuates doxorubicin-induced acute cardiotoxicity without interfering with its anticancer effects.
Relationships between hemodynamic, hemorheological and metabolic responses during exercise.
Assessment of the relationships between hemodynamic, hemorheological and metabolic parameters in response to a sub-maximal cycling exercise protocol suggested a potential role for RBC deformability as a factor affecting aerobic performance via oxygen delivery to tissues.
Effects of Moderate Aerobic Exercise Training on Hemorheological and Laboratory Parameters in Ischemic Heart Disease Patients
Regular physical training improved the exercise tolerability of patients with ischemic heart disease and positive changes in laboratory parameters and body weight may indicate better oxidative and inflammatory circumstances and an improved metabolic state.