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CaM kinase Iα–induced phosphorylation of Drp1 regulates mitochondrial morphology
Ca2+ is likely to be functionally important in the control of mitochondrial dynamics through regulation of Drp1 phosphorylation in neurons and other cell types, suggesting that CaMKIα is a widely expressed protein kinase.
Spinophilin regulates the formation and function of dendritic spines.
Evidence is provided that spinophilin modulates both glutamatergic synaptic transmission and dendritic morphology and deletion of the spinophILin gene caused a marked increase in spine density during development in vivo as well as altered filopodial formation in cultured neurons.
Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP–32 and spinophilin
Modulation of AMPA–type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP–1)…
Oxytocin improves long-lasting spatial memory during motherhood through MAP kinase cascade
This work shows a new function of oxytocin in causing plastic changes in hippocampal synapses during motherhood, and indicates that the hormone is critically involved in improving hippocampus-dependent learning and memory in mice.
Channel Function Is Dissociated from the Intrinsic Kinase Activity and Autophosphorylation of TRPM7/ChaK1*
It is concluded that neither current activity nor regulation by internal Mg2+ is affected by kinase activity or autophosphorylation but that the kinase domain may play a structural role in channel assembly or subcellular localization.
An Isoform of the Neuronal Cyclin-dependent Kinase 5 (Cdk5) Activator (*)
A distinct clone encoding a 39-kDa isoform of Nck5a shares many common characteristics with p35, including Ckd5 activating activity and brain- and neuron-specific expression, suggesting that they define a new family of cyclin-dependent kinase-activating proteins.
Critical Role of Calpain-mediated Cleavage of Calcineurin in Excitotoxic Neurodegeneration*
It is reported that during neuroexcitotoxicity, calcineurin A (CnA) is directly cleaved by calpain in vitro and in vivo, resulting in the enzyme being converted to an active form, thereby demonstrating a new mechanism for proteolytical regulation of calcineURin by Calpain in response to certain pathological states.
Cophosphorylation of amphiphysin I and dynamin I by Cdk5 regulates clathrin-mediated endocytosis of synaptic vesicles
It is shown that Cdk5/p35-dependent cophosphorylation of amphiphysin I and dynamin I plays a critical role in clathrin-mediated endocytosis and was undetectable in p35-deficient mice.
Ciliary transition zone activation of phospho-Tctex-1 controls ciliary resorption, S-phase entry and fate of neural progenitors
Results support a model in which the cilia act as a brake to prevent cell cycle progression, and show the involvement of actin dynamics in Tctex-1-regulated cilium resorption.
Cdk5/p35 Regulates Neurotransmitter Release through Phosphorylation and Downregulation of P/Q-Type Voltage-Dependent Calcium Channel Activity
Results strongly suggest that Cdk5/p35 inhibits neurotransmitter release through the phosphorylation of P/Q-type VDCC and downregulation of the channel activity.