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Fission yeast Ccq1 is telomerase recruiter and local checkpoint controller.
Telomeres recruit telomerase and differentiate chromosome ends from sites of DNA damage. Although the DNA damage checkpoint PI3-kinases ATM and ATR localize to telomeres and promote telomeraseExpand
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The Telomere Bouquet Controls the Meiotic Spindle
Bouquet formation, in which telomeres gather to a small region of the nuclear membrane in early meiosis, has been observed in diverse eukaryotes, but the function of the bouquet has remained aExpand
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Telomeres and centromeres have interchangeable roles in promoting meiotic spindle formation
Both centromere–centrosome and telomere–centrosome contacts can promote spindle formation during meiosis.
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Fundamental mechanisms of telomerase action in yeasts and mammals: understanding telomeres and telomerase in cancer cells
Aberrant activation of telomerase occurs in 85–90% of all cancers and underpins the ability of cancer cells to bypass their proliferative limit, rendering them immortal. The activity of telomerase isExpand
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Telomerase Activation after Recruitment in Fission Yeast
Summary Current models depict that telomerase recruitment equates to activation. Telomeric DNA-binding proteins and the telomerase accessory proteins coordinate the recruitment of telomerase to theExpand
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Telomere protein Rap1 is a charge resistant scaffolding protein in chromosomal bouquet formation
BackgroundChromosomes reorganize in early meiotic prophase to form the so-called telomere bouquet. In fission yeast, telomeres localize to the nuclear periphery via interaction of the telomericExpand
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A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.
Replication protein A (RPA) is a heterotrimeric single-stranded DNA-binding protein involved in DNA replication, recombination and repair. In Saccharomyces cerevisiae, several mutants in the RFA1Expand
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Fission yeast Rhp51 is required for the maintenance of telomere structure in the absence of the Ku heterodimer.
The Schizosaccharomyces pombe Ku70-Ku80 heterodimer is required for telomere length regulation. Lack of pku70+ results in telomere shortening and striking rearrangements of telomere-associatedExpand
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LARP7 family proteins have conserved function in telomerase assembly
Understanding the intricacies of telomerase regulation is crucial due to the potential health benefits of modifying its activity. Telomerase is composed of an RNA component and reverse transcriptase.Expand
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How long does telomerase extend telomeres? Regulation of telomerase release and telomere length homeostasis
  • K. Tomita
  • Biology, Medicine
  • Current Genetics
  • 16 April 2018
Telomerase, the enzyme that replenishes telomeres, is essential for most eukaryotes to maintain their generations. Telomere length homeostasis is achieved via a balance between telomere lengtheningExpand
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