K. Thornburg

Publications329
h-index53
Citations12,766
Highly Influential Citations349
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Effect of in utero and early-life conditions on adult health and disease.
TLDR
Evidence from several disciplines is synthesized to support the contention that environmental factors acting during development should be accorded greater weight in models of disease causation.
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Boys live dangerously in the womb
TLDR
Boy's placentas may be more efficient than girls, but may have less reserve capacity; boys' greater dependence on their mothers' diets may enable them to capitalize on an improving food supply, but it makes them vulnerable to food shortages.
View on Wiley
Nutrition in adolescents: physiology, metabolism, and nutritional needs
TLDR
The physiology, metabolism, and nutritional requirements for adolescents and pregnant adolescents, as well as nutrition‐related behavior and current trends in adolescent nutrition are described, with thoughts on the implications for nutrition interventions and priority areas that would require further investigation.
View on Wiley
Central shunt flows and pressures in the mature fetal lamb.
TLDR
Fetal systemic somatic blood flow showed a reliable negative correlation with the oxygen tension in the fetal arterial blood and was taken as presumptive evidence for long-term autoregulation of flow in the peripheral tissues.
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Beneficial and cautionary outcomes of resveratrol supplementation in pregnant nonhuman primates
TLDR
It is demonstrated that resveratrol use during pregnancy yields improvements in maternal and placental phenotype with beneficial effects in the fetal liver but an unexplained and concerning alteration in fetal pancreatic development, which strongly cautions against the use of resver atrol by pregnant women.
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Placental Origins of Chronic Disease.
TLDR
The complex relationships between the placental phenotype and developmental programming of chronic disease in the offspring are explored, offering a new approach to the prevention of disorders such as cardiovascular disease, diabetes, and obesity, which are reaching epidemic proportions.
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Maternal high-fat diet impacts endothelial function in nonhuman primate offspring
TLDR
The data indicate that maternal HFD exposure impairs offspring's endothelial function, and both early programming events and postweaning diet contribute to the abnormalities that could be reversed partially by diet intervention.
View on Nature
Pre-Eclampsia Is Associated With Increased Risk of Stroke in the Adult Offspring: The Helsinki Birth Cohort Study
TLDR
People born after pregnancies complicated by pre-eclampsia or gestational hypertension are at increased risk of stroke, and the underlying processes may include a local disorder of the blood vessels of the brain as a consequence of either reduced brain growth or impaired brain growth leading to “brain-sparing” responses in utero.
View on Wolters Kluwer
Maternal high-fat diet disturbs uteroplacental hemodynamics and increases the frequency of stillbirth in a nonhuman primate model of excess nutrition.
TLDR
It is shown that HFD consumption by obese mothers with hyperinsulinemia also reduced volume blood flow on the fetal side of the placenta and significantly increased the frequency of both placental infarctions and stillbirth.
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Myocyte enlargement, differentiation, and proliferation kinetics in the fetal sheep heart.
TLDR
Cardiac growth was in part due to enlargement of 3) mononucleated and 4) binucleated myocytes, which grew in cross-sectional diameter but not length during the last third of gestation.
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