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Molecular characterization of a peripheral receptor for cannabinoids
THE major active ingredient of marijuana, Δ9-tetrahydrocannabi-nol (Δ9-THC), has been used as a psychoactive agent for thousands of years. Marijuana, and Δ9-THC, also exert a wide range of otherExpand
Independent Cellular Processes for Hippocampal Memory Consolidation and Reconsolidation
The idea that new memories undergo a time-dependent consolidation process after acquisition has received considerable experimental support. More controversial has been the demonstration thatExpand
Enhanced and Impaired Attentional Performance After Infusion of D1 Dopaminergic Receptor Agents into Rat Prefrontal Cortex
The role in spatial divided and sustained attention of D1 and D2-like dopamine (DA) receptors in the rat prelimbic medial prefrontal cortex (mPFC) was investigated in a five-choice serial reactionExpand
Rapid and selective induction of BDNF expression in the hippocampus during contextual learning
The hippocampus is required for many forms of long-term memory in both humans and animals, and formation of long-lasting memories requires the synthesis of new proteins. Furthermore, the long-termExpand
A Simple Role for BDNF in Learning and Memory?
Since its discovery almost three decades ago, the secreted neurotrophin brain-derived neurotrophic factor (BDNF) has been firmly implicated in the differentiation and survival of neurons of the CNS.Expand
Cellular Imaging of zif268 Expression in the Hippocampus and Amygdala during Contextual and Cued Fear Memory Retrieval: Selective Activation of Hippocampal CA1 Neurons during the Recall of Contextual
The neuroanatomical and molecular basis of fear memory retrieval was studied by analyzing the expression of the plasticity-associated immediate early gene zif268. Cellular quantitative in situExpand
Fear memory retrieval induces CREB phosphorylation and Fos expression within the amygdala
Fear memory retrieval has been shown to induce a protein‐synthesis dependent re‐consolidation of memories within the amygdala. Here, using immunocytochemistry, we investigated the molecular basis ofExpand
Disrupting Reconsolidation of Drug Memories Reduces Cocaine-Seeking Behavior
Maladaptive memories that associate environmental stimuli with the effects of drugs of abuse are known to be a major cause of relapse to, and persistence of, a drug addictive habit. However, memoriesExpand
Induction of the learning and plasticity‐associated gene Zif268 following exposure to a discrete cocaine‐associated stimulus
We investigated whether the expression of the plasticity‐associated gene, zif268, was associated with memories retrieved by exposure to a discrete stimulus that had been associated with cocaine,Expand
Proteolysis of proBDNF Is a Key Regulator in the Formation of Memory
It is essential to understand the molecular processes underlying long-term memory to provide therapeutic targets of aberrant memory that produce pathological behaviour in humans. Under conditions ofExpand