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The patch clamp technique.
The introduction of the patch clamp technique less than two decades ago revolutionized the study of cellular physiology by providing a high-resolution method of observing the function of individualExpand
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FLUORIDE AND/OR ARSENIC TOXICITY IN MICE TESTIS WITH FORMATION OF GIANT CELLS AND SUBSEQUENT RECOVERY BY SOME ANTIDOTES
SUMMARY: Administration of sodium fluoride (NaF, 5 mg/kg body weight) and/or arsenic trioxide (As2O3, 0.5 mg/kg body weight) for 30 days caused structural alterations (including the formation ofExpand
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Sodium nitroprusside and cGMP decrease Ca2+ channel availability in basilar artery smooth muscle cells
Abstract We studied the effect of the nitric oxide (NO) donor, sodium nitroprusside (SNP), on the macroscopic and single-channel currents due to the 22-pS Ca2+ channel in smooth muscle cells fromExpand
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Calcium channels in smooth muscle cells from cerebral precapillary arterioles activate at more negative potentials than those from basilar artery
We compared Ca2+ channels in cell-attached patches of smooth muscle cells from cerebral precapillary arterioles and basilar artery of guinea pig. Patches were studied without Ca2+ channel activatorsExpand
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Protein kinase A increases availability of calcium channels in smooth muscle cells from guinea pig basilar artery
We studied single Ca2+ channels in smooth muscle cells from the basilar artery of the guinea pig using conventional patch-clamp techniques. With 40 mM or 90 mM Ba2+ as the charge carrier, a 23-pSExpand
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Early signaling events by endotoxin in PC12 cells: Involvement of tyrosine kinase, constitutive nitric oxide synthase, cGMP‐dependent protein kinase, and Ca2+ channels
We studied the effects of endotoxin from Escherichia coli (E. coli) on Ca2+ channel activity in PC12 cells using the cell‐attached patch clamp technique. Endotoxin (1–100 ng/ml) decreased channelExpand
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Ionic channel currents in cultured neurons from human cortex
Ionic channels in human cortical neurons have not been studied extensively. HCN‐1 and HCN‐1A cells, which recently were established as continuous cultures from human cortical tissue, have been shownExpand
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Acetyl‐L‐Carnitine arginyl amide (ST857) increases calcium channel density in rat pheochromocytoma (PC12) cells
We used the patch clamp technique to study the effect of acetyl‐L‐carnitine arginyl amide (ALCAA) and of nerve growth factor (NGF) on availability of L‐type Ca2+ channels in rat pheochromocytomaExpand
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