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- Publications
- Influence
Isoflavonoid glycosides from Dalbergia sissoo.
- S. F. Farag, A. Ahmed, K. Terashima, Y. Takaya, M. Niwa
- Chemistry, Medicine
- Phytochemistry
- 1 August 2001
Two isoflavone glycosides, biochanin A 7-O-[beta-D-apiofuranosyl-(1-->5)-beta-D-apiofuranosyl-(1-->6)-beta-D-glucopyranoside] and tectorigenin… Expand
Structure-activity relationship of small-sized HIV protease inhibitors containing allophenylnorstatine.
- T. Mimoto, R. Kato, +9 authors H. Hayashi
- Chemistry, Medicine
- Journal of medicinal chemistry
- 20 May 1999
We designed and synthesized a new class of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns; (2S,… Expand
Structure-activity relationship of orally potent tripeptide-based HIV protease inhibitors containing hydroxymethylcarbonyl isostere.
- T. Mimoto, Naohiko Hattori, +14 authors Y. Kiso
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 1 September 2000
We designed and synthesized a new class of peptidomimetic human immunodeficiency virus protease inhibitors containing a unique unnatural amino acid, allophenylnorstatine [Apns;… Expand
Purification and Partial Characterization of an Indomethacin Hydrolyzing Enzyme from Pig Liver
- K. Terashima, S. Takai, +4 authors K. Hirano
- Biology, Medicine
- Pharmaceutical Research
- 1 September 1996
AbstractPurpose. Indomethacin is well known to be metabolized via O-demethylation and N-deacylation. In this paper we found an enzyme involved in the hydrolysis of amide-linkage of indomethacin and… Expand
Studies on antiulcer agents. IV. Antiulcer effects of 2-benzylthio5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds.
- K. Terashima, H. Shimamura, +5 authors M. Sato
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 15 November 1995
With a view to finding more effective antiulcer agents, a series of 2-benzylthio-5,6,7,8-tetrahydro-4(3H)-quinazolinones and related compounds were synthesized and evaluated in a histamine-stimulated… Expand
Structure-activity and structure-metabolism relationships of HIV protease inhibitors containing the 3-hydroxy-2-methylbenzoyl-allophenylnorstatine structure.
- T. Mimoto, K. Terashima, +5 authors H. Hayashi
- Chemistry, Medicine
- Bioorganic & medicinal chemistry
- 2 January 2004
A series of peptidomimetic human immunodeficiency virus (HIV) protease inhibitors containing substituted all-phenylnorstatine [APNS: (2S,3S)-3-amino-2-hydroxy-4-phenylbutyric acid] were designed and… Expand
Separation of carnitine enantiomers as the 9-anthroylnitrile derivatives and high-performance liquid chromatographic analysis on an ovomucoid-conjugated column.
- M. Takahashi, K. Terashima, M. Nishijima, K. Kamata
- Chemistry, Medicine
- Journal of pharmaceutical and biomedical analysis
- 1 August 1996
9-Anthroylnitrile was used as an achiral reagent for the derivatization of carnitine. The reagent forms UV-absorbing derivatives with the hydroxyl groups of carnitine enantiomers under very mild… Expand
Neuronal nitric oxide synthase specific autophosphorylation in baculovirus/Sf9 insect cell system.
- Y. Watanabe, K. Terashima, H. Hidaka
- Biology, Medicine
- Biochemical and biophysical research…
- 15 February 1996
Neuronal nitric oxide synthase (nNOS) is a calmodulin (CaM)-dependent enzyme, which generates the ubiquitous biological mediator nitric oxide. In this study, wild-type or mutant form of rat nNOS was… Expand
Purification and properties of protoporphyrinogen oxidase from spinach chloroplasts.
- N. Watanabe, F. Che, K. Terashima, S. Takayama, S. Yoshida, A. Isogai
- Chemistry, Medicine
- Plant & cell physiology
- 15 July 2000
Protoporphyrinogen oxidase (Protox), an enzyme that catalyzes the common step of chlorophyll and heme biosynthetic pathways, was purified from spinach chloroplasts. The molecular weight of purified… Expand
Studies on antiulcer agents. II. Antiulcer properties of N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides inhibiting release of histamine from passively sensitized rat peritoneal mast cells.
- K. Terashima, T. Tanimura, +7 authors M. Sato
- Chemistry, Medicine
- Chemical & pharmaceutical bulletin
- 15 June 1995
With the aim of applying mast cell-stabilizing agents as antiulcer agents, N-(1H-tetrazol-5-yl)-2-anilino-5-pyrimidinecarboxamides were synthesized, and initially evaluated pharmacologically for… Expand