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Reduced Lung-Cancer Mortality with Volume CT Screening in a Randomized Trial.
- H. D. de Koning, C. van der Aalst, +21 authors M. Oudkerk
- The New England journal of medicine
- 29 January 2020
BACKGROUND There are limited data from randomized trials regarding whether volume-based, low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among male former and current… Expand
Detection of lung cancer through low-dose CT screening (NELSON): a prespecified analysis of screening test performance and interval cancers.
BACKGROUND Low-dose CT screening is recommended for individuals at high risk of developing lung cancer. However, CT screening does not detect all lung cancers: some might be missed at screening, and… Expand
Benefits and Harms of Computed Tomography Lung Cancer Screening Strategies: A Comparative Modeling Study for the U.S. Preventive Services Task Force
The burden of lung cancer in the world remains extremely high: The International Agency for Research on Cancer estimated 1.6 million new diagnoses in 2008 (12.7% of total cases of cancer) and 1.4… Expand
Lung cancer probability in patients with CT-detected pulmonary nodules: a prespecified analysis of data from the NELSON trial of low-dose CT screening.
BACKGROUND The main challenge in CT screening for lung cancer is the high prevalence of pulmonary nodules and the relatively low incidence of lung cancer. Management protocols use thresholds for… Expand
Risk prediction models for selection of lung cancer screening candidates: A retrospective validation study
Background Selection of candidates for lung cancer screening based on individual risk has been proposed as an alternative to criteria based on age and cumulative smoking exposure (pack-years). Nine… Expand
Performance and Cost-Effectiveness of Computed Tomography Lung Cancer Screening Scenarios in a Population-Based Setting: A Microsimulation Modeling Analysis in Ontario, Canada
Background The National Lung Screening Trial (NLST) results indicate that computed tomography (CT) lung cancer screening for current and former smokers with three annual screens can be cost-effective… Expand
Final screening round of the NELSON lung cancer screening trial: the effect of a 2.5-year screening interval
Background In the USA annual lung cancer screening is recommended. However, the optimal screening strategy (eg, screening interval, screening rounds) is unknown. This study provides results of the… Expand
Occurrence and lung cancer probability of new solid nodules at incidence screening with low-dose CT: analysis of data from the randomised, controlled NELSON trial.
BACKGROUND US guidelines now recommend lung cancer screening with low-dose CT for high-risk individuals. Reports of new nodules after baseline screening have been scarce and are inconsistent because… Expand
Comparing Benefits from Many Possible Computed Tomography Lung Cancer Screening Programs: Extrapolating from the National Lung Screening Trial Using Comparative Modeling
Background The National Lung Screening Trial (NLST) demonstrated that in current and former smokers aged 55 to 74 years, with at least 30 pack-years of cigarette smoking history and who had quit… Expand
The impact of overdiagnosis on the selection of efficient lung cancer screening strategies
The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low‐dose computed tomography (LDCT) for lung cancer (LC) screening through… Expand