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A small molecule inhibitor of p53-inducible protein phosphatase PPM1D.
TLDR
It is shown that SPI-001 was a potent and specific PPM1D inhibitor and a potential lead compound in developing anti-cancer drugs. Expand
Novel inhibitors targeting PPM1D phosphatase potently suppress cancer cell proliferation.
TLDR
It is demonstrated that a specific inhibitor, SL-176 that can be readily synthesized in 10 steps, significantly inhibits proliferation of a breast cancer cell line overexpressing PPM1D and induces G2/M arrest and apoptosis and could be a useful lead compound in the development of effective anti-cancer agents. Expand
Adsorption characteristics of tryptic fragments of bovine beta-lactoglobulin on a stainless steel surface.
TLDR
Results indicated that the carboxyl groups on the side chains of the peptides play an important role in the adsorption of bovine beta-lactoglobulin. Expand
Inhibition of Ser/Thr phosphatase PPM1D induces neutrophil differentiation in HL-60 cells
TLDR
It is found that inhibition of PPM1D induced neutrophil differentiation of human promyelocytic leukemia cell line HL-60 and the combination of a P PM1D inhibitor and all-trans retinoic acid significantly increased their differentiation efficiency. Expand
Inhibition of C-terminal truncated PPM1D enhances the effect of doxorubicin on cell viability in human colorectal carcinoma cell line.
TLDR
It is shown that combination treatment with PPM1D-specific inhibitor SPI-001 and doxorubicin suppressed cell viability of HCT-116 cells overexpressing C-terminal truncated P PM1D through p53 activation compared with doxorbicin alone. Expand
Total Synthesis of Norzoanthamine
TLDR
This work reports the stereoselective total synthesis of norzoanthamine in 41 steps, with an overall yield of 3.5% (an average of 92% yield each step). Expand
Total synthesis of ingenol.
TLDR
The highly strained ingenane skeleton was constructed through an intramolecular cyclization reaction of an acetylene dicobalt complex followed by a rearrangement Reaction of an epoxy alcohol. Expand
Direct synthesis of fluorescent 1,3a,6a-triazapentalene derivatives via click-cyclization-aromatization cascade reaction.
TLDR
The 1,3a,6a-triazapentalene skeleton without an additional fused ring system was discovered to be a compact and highly fluorescent chromophore, which exhibited various interesting fluorescent properties. Expand
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