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Structure and functions of the 20S and 26S proteasomes.
TLDR
Major advances have been achieved recently in knowledge about the molecular organization of the 20S and 19S particles, their subunits, the proteasome's role in MHC-class 1 antigen presentation, and regulators of its activities. Expand
A hierarchical quorum‐sensing cascade in Pseudomonas aeruginosa links the transcriptional activators LasR and RhIR (VsmR) to expression of the stationary‐phase sigma factor RpoS
TLDR
Results indicate that P. aeruginosa employs a multilayered hierarchical quorum‐sensing cascade involving RhIR/BHL and LasR/OdDHL, interlinked via RpoS, to integrate the regulation of virulence determinants and secondary metabolites with adaptation and survival in the stationary phase. Expand
A downstream target of RHO1 small GTP‐binding protein is PKC1, a homolog of protein kinase C, which leads to activation of the MAP kinase cascade in Saccharomyces cerevisiae.
TLDR
Results indicate that there are at least two signaling pathways regulated by Rho1p and that one of the downstream targets is Pkc1p, leading to the activation of the MAP kinase cascade. Expand
Rom1p and Rom2p are GDP/GTP exchange proteins (GEPs) for the Rho1p small GTP binding protein in Saccharomyces cerevisiae.
TLDR
Results indicate that Rom1p and Rom2p are GEPs that activate Rho1p in S.cerevisiae, a homolog of the mammalian RhoA small GTP binding protein in the yeast Saccharomyces cerevisiae. Expand
Rho1p-Bni1p-Spa2p interactions: implication in localization of Bni1p at the bud site and regulation of the actin cytoskeleton in Saccharomyces cerevisiae.
TLDR
Results indicate that both Rho1p and Spa2p are involved in the localization of Bni1p at the growth sites where Rho2p regulates reorganization of the actin cytoskeleton through BNI1p. Expand
The fission yeast gamma-tubulin is essential for mitosis and is localized at microtubule organizing centers.
TLDR
Results confirm that gamma- Tubulin is an important member of the tubulin superfamily, suggest that it may be a universal component of MTOCs, and are consistent with a role for gamma-tubulin in controlling microtubule formation in vivo. Expand
Bni1p implicated in cytoskeletal control is a putative target of Rho1p small GTP binding protein in Saccharomyces cerevisiae.
TLDR
The results suggest that Rho1p regulates cytoskeletal reorganization at least through Bni1p and Pkc1p. Expand
Interaction of Bnr1p with a Novel Src Homology 3 Domain-containing Hof1p
TLDR
It is shown that Bnr1p directly interacts with Hof1p as well as with profilin to regulate cytoskeletal functions in S. cerevisiae, indicating that HOF1 is involved in cytokinesis. Expand
Systematic mutational analysis revealing the functional domain organization of Escherichia coli nucleoid protein H-NS.
TLDR
Three distinct functional domains were found in H-NS, which appear to be responsible for DNA-binding, transcriptional repression and protein-protein interaction (dimerization and/or oligomerization), respectively. Expand
Molecular cloning and characterization of a new human histamine receptor, HH4R.
TLDR
Observations indicate that the clone is a distinct histamine receptor from HH3R, and thus is named HH4R, which was cloned from human leukocyte cDNA. Expand
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