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All-trans-retinoic acid modulates expression levels of thyroglobulin and cytokines in a new human poorly differentiated papillary thyroid carcinoma cell line, KTC-1.
Histological findings by light and electron microscopy indicated transplanted tumors to be a poorly differentiated papillary thyroid carcinoma, and RT-PCR analysis of retinoic acid receptors revealed that KTC-1 cells express a moderate level of RARalpha and -gamma, but a low level ofRARbeta, which may be useful for studying redifferentiation therapy for thyroid carcinomas.
Hormonal responses to insulin-induced hypoglycemia in man.
It is suggested that multiple ACTH-releasing factors, such as CRH, AVP, E, and NE, are involved in ACTH secretion induced by insulin-induced hypoglycemia in man.
Role of endogenous arginine vasopressin in potentiating corticotropin-releasing hormone-stimulated corticotropin secretion in man.
Exogenously administered vasopressin (VP) augments ACTH secretion stimulated by CRH and plays a physiologically significant role in regulating CRH-stimulated ACTH and cortisol secretion in man.
Thiazolidinediones inhibit osteoclast-like cell formation and bone resorption in vitro.
Inhibitory effects of TZDs on osteoclastic bone resorption was not osteotropic factor specific and did not appear to be related to their adipogenic effects, indicating that T ZDs are potent inhibitors of bone Resorption in vitro.
HLA and thyrotoxic periodic paralysis in Japanese patients.
The data suggest that the HLA-DRw8 gene itself may play a significant role in the susceptibility to TPP among Japanese men.
Type-II thyroxine 5'-deiodinase is present in the rat pineal gland.
Rhythmicity of triiodothyronine generation by type II thyroxine 5'-deiodinase in rat pineal is mediated by a beta-adrenergic mechanism.
A previously unrecognized role of thyroid hormone in pineal regulation is suggested, as its activity in the rat pineal was 20-30 times higher at midnight than at noon; this nocturnal rise was abolished by the beta-adrenergic blocker, propranolol.
Cytoplasmic progesterone receptor concentrations in the hen hypothalamus and pituitary: difference between laying and nonlaying hens and changes during the ovulatory cycle.
The maximum number of binding sites per mg protein of cytoplasmic progesterone receptors in the hypothalamus and pituitary was greater in laying hens than in nonlaying hens, while the value of
Studies on the contractility of follicular wall with special reference to the mechanism of ovulation in hens.
It is suggested that the contraction of the follicular wall promotes the rupture of the stigma at ovulation and the neurotransmitters as well as prostaglandins and OOIF may be involved in this event.
High affinity 3,5,3'-L-triiodothyronine binding to synaptosomes in rat cerebral cortex.
Findings clearly indicate that there exist specific T3-binding sites in synaptosomes from rat cerebral cortex, and the MBC of the higher affinitysynaptosomal T3binding sites was low in 2-day-old rats and increased thereafter to the level in young adult ras.