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The C-Reactive Protein/Albumin Ratio, a Novel Inflammation-Based Prognostic Score, Predicts Outcomes in Patients with Hepatocellular Carcinoma
The CRP/Alb ratio might be an independent prognostic marker in patients with HCC, and may have comparable prognostic ability to other established inflammation-based prognostic scores. Expand
Realistic Animation of Fluid with Splash and Foam
A method for modeling and rendering dynamic behavior of fluids with splashes and foam using the Cubic Interpolated Propagation method, which provides dynamic and realistic scenes in a short time. Expand
Synthesis and activity of oleanolic acid derivatives, a novel class of inhibitors of osteoclast formation.
- Y. Zhang, Jian-Xin Li, +4 authors S. Kadota
- Chemistry, Medicine
- Bioorganic & medicinal chemistry letters
- 15 March 2005
Two series of oleanolic acid derivatives were synthesized and their inhibitory activity on the formation of osteoclast-like multinucleated cells (OCLs) induced by 1alpha,25-dihydroxy vitamin D3 was… Expand
Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.
- R. Kin, S. Kato, +6 authors S. Yokoyama
- Biology, Medicine
- International journal of oncology
- 1 December 2013
It is newly determined that only the Cinnamomi Cortex (CC) extract, one of 10 herbal components of Juzentaihoto, inhibits TGF-β-induced EMT, and that procyanidin C1 could be useful as a lead compound to develop inhibitors of cancer metastasis and other diseases related to EMT. Expand
Elevated Plasma Fibrinogen Levels Are Associated with a Poor Prognosis in Patients with Hepatocellular Carcinoma
This study demonstrates that elevated pretreatment plasma fibrinogen levels are associated with tumor progression and are independently associated with a poor prognosis in patients with HCC. Expand
The Glasgow Prognostic Score, an inflammation based prognostic score, predicts survival in patients with hepatocellular carcinoma
It is demonstrated that the GPS can serve as an independent marker of poor prognosis in patients with HCC in various stages of disease and different liver functional status. Expand
Highly enantioselective construction of axial chirality by palladium-catalyzed cycloisomerization of N-alkenyl arylethynylamides.
- H. Imase, T. Suda, Y. Shibata, K. Noguchi, M. Hirano, K. Tanaka
- Chemistry, Medicine
- Organic letters
- 12 March 2009
The present catalysis represents the first enantioselective construction of axial chirality by the transition-metal-catalyzed cycloisomerization of N-alkenyl arylethynylamides leading to axially chiral 4-aryl-2-pyridones in high yields with high ee values. Expand
Six Novel Diarylheptanoids Bearing Chalcone or Flavanone Moiety from the Seeds of Alpinia blepharocalyx.
Efficacy prediction of jamu formulations by PLS modeling.
- F. M. Afendi, L. K. Darusman, +5 authors S. Kanaya
- Mathematics, Medicine
- Current computer-aided drug design
- 28 February 2013
This work modeled the ingredients of Jamu formulas using Partial Least Squares Discriminant Analysis (PLS-DA) in order to predict their efficacy, and determined the efficacy for which a plant is most useful, based on its largest coefficients. Expand
On the computational capability of recurrent higher-order neural networks
This paper demonstrates that a recurrent higher-order neural network can simulate any Turing machine in real time, and shows that the number of neurons required to simulate the tape can be reduced to six, and offers a simplified simulation model as a viable framework for learning formal language using a neural network. Expand