• Publications
  • Influence
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
TLDR
The authors declare competing financial interests: see the website (http://medicine.nature.com) for details. Expand
Tumor-associated B7-H1 promotes T-cell apoptosis: A potential mechanism of immune evasion
TLDR
It is reported here that, except for cells of the macrophage lineage, normal human tissues do not express B7-H1 and the findings have implications for the design of T cell–based cancer immunotherapy. Expand
B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
TLDR
A previously unknown co-stimulatory molecule that may be involved in the negative regulation of cell-mediated immune responses is defined. Expand
B7-H3: a costimulatory molecule for T cell activation and IFN-gamma production.
TLDR
A newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20-27% amino acid identity with other B7family members is described, that may participate in the regulation of cell-mediated immune responses. Expand
B7-H4, a molecule of the B7 family, negatively regulates T cell immunity.
TLDR
A B7 family molecule, B7-H4, is identified by protein sequence analysis and comparative molecular modeling and may participate in negative regulation of cell-mediated immunity in peripheral tissues. Expand
B7-H3: A costimulatory molecule for T cell activation and IFN-γ production
TLDR
A newly identified member of the human B7 family, designated B7 homolog 3 (B7-H3), that shares 20–27% amino acid identity with other B7family members is described, that may participate in the regulation of cell-mediated immune responses. Expand
53BP1 is required for class switch recombination
TLDR
The data indicate that homologous recombination by gene conversion does not depend on 53BP1, and mice deficient in the tumor suppressors ATM and H2AX support normal V(D)J recombination, indicating that 53 BP1 is not required for “classic” nonhomologous end joining. Expand
B7-H1 blockade augments adoptive T-cell immunotherapy for squamous cell carcinoma.
TLDR
Data support B7-H1 blockade as a new approach to enhance the efficacy of T-cell immunotherapy. Expand
Modulation of T-cell-mediated immunity in tumor and graft-versus-host disease models through the LIGHT co-stimulatory pathway
TLDR
These studies identify a previously unknown T-cell co-stimulatory pathway as a potential therapeutic target and isolate a mouse homolog of human LIGHT, a member of the tumor necrosis factor (TNF) ‘superfamily’. Expand
Blockade of B7-H1 and PD-1 by monoclonal antibodies potentiates cancer therapeutic immunity.
TLDR
It is reported here that constitutive or inducible expression of B7-H1, a B7 family molecule widely expressed by cancers, confers resistance to therapeutic anti-CD137 antibody in mice with established tumors and implicate new approaches for immunotherapy of human cancers. Expand
...
1
2
3
4
5
...