Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
- K. Takayama, K. Horie-Inoue, S. Inoue
- BiologyEMBO Journal
- 12 June 2013
An androgen‐responsive long ncRNA, CTBP1‐AS, located in the AS region of C‐terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor is reported, providing new insights into the functions of ncRNAs that directly contribute to prostate cancer progression.
PAPD5-mediated 3′ adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease
- J. Boele, H. Persson, Michiel J L de Hoon
- BiologyProceedings of the National Academy of Sciences
- 21 July 2014
It is found that disruption of the miR-21 adenylation and degradation pathway is a general feature in tumors across a wide range of tissues, as evidenced by data from The Cancer Genome Atlas, as well as in the noncancerous proliferative disease psoriasis.
Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis
- K. Takayama, K. Kaneshiro, S. Inoue
- BiologyOncogene
- 28 June 2007
This study identified androgen target genes that are directly regulated by AR in LNCaP cells, by combining chromatin immunoprecipitation with tiling microarrays (ChIP-chip) and ENCODE array, and focused on UGT1A and CDH2 as AR target genes.
Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.
- Hitoshi Aihara, Takeya Nakagawa, Takashi Ito
- Biology, ChemistryMolecules and Cells
- 6 October 2016
Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer
- K. Takayama, Takashi Suzuki, T. Fujimura, Satoru Takahashi, S. Inoue
- BiologyMolecular Cancer Research
- 29 January 2018
The oncogenic role of USP10 is elucidated through an increase in G3BP2 protein that inhibits p53 activity, in addition to the promotion of AR signaling, which highlights an importantOncogenic aspect of USp10 through its modulation of the p53–G3 BP2 complex and AR signaling in prostate cancer.
Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF
- K. Takayama, Takashi Suzuki, S. Inoue
- BiologyProceedings of the National Academy of Sciences
- 11 September 2017
It is revealed that various spliceosome genes are aberrantly induced by RNA-binding protein PSF, leading to enhancement of the splicing activities for AR expression, suggesting a role of RNA- binding protein for AR activation for prostate cancer progression.
Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth.
- K. Takayama, S. Tsutsumi, S. Inoue
- Biology, MedicineCancer Research
- 2009
The present study reveals a novel APP-mediated pathway responsible for the androgen-dependent growth of prostate cancer and indicates that APP could be a potential molecular target for the diagnosis and treatment of Prostate cancer.
Integration of cap analysis of gene expression and chromatin immunoprecipitation analysis on array reveals genome-wide androgen receptor signaling in prostate cancer cells
- K. Takayama, S. Tsutsumi, S. Inoue
- BiologyOncogene
- 3 February 2011
The integrated high-throughput genome analyses of CAGE and ChIP-chip provide useful information for elucidating the AR-mediated transcriptional network that contributes to the development and progression of PCa.
Prostate cancer-associated lncRNAs.
- Y. Mitobe, K. Takayama, K. Horie-Inoue, S. Inoue
- BiologyCancer Letters
- 1 April 2018
Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells*
- A. Misawa, K. Takayama, T. Urano, S. Inoue
- BiologyJournal of Biological Chemistry
- 24 June 2016
It is demonstrated that SOCS2-AS1 plays an important role in the development of castration-resistant prostate cancer by repressing apoptosis by modulating the epigenetic control for AR target genes including TNFSF10.
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