K. Takayama

Publications90
h-index29
Citations2,489
Highly Influential Citations59
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Androgen‐responsive long noncoding RNA CTBP1‐AS promotes prostate cancer
TLDR
An androgen‐responsive long ncRNA, CTBP1‐AS, located in the AS region of C‐terminal binding protein 1 (CTBP1), which is a corepressor for androgen receptor is reported, providing new insights into the functions of ncRNAs that directly contribute to prostate cancer progression. Expand
Identification of novel androgen response genes in prostate cancer cells by coupling chromatin immunoprecipitation and genomic microarray analysis
TLDR
This study identified androgen target genes that are directly regulated by AR in LNCaP cells, by combining chromatin immunoprecipitation with tiling microarrays (ChIP-chip) and ENCODE array, and focused on UGT1A and CDH2 as AR target genes. Expand
Histone H2A T120 Phosphorylation Promotes Oncogenic Transformation via Upregulation of Cyclin D1.
TLDR
The results suggest that histone H2A T120 phosphorylation by hVRK1 causes inappropriate gene expression, including upregulated cyclin D1, which promotes oncogenic transformation. Expand
PAPD5-mediated 3′ adenylation and subsequent degradation of miR-21 is disrupted in proliferative disease
TLDR
It is found that disruption of the miR-21 adenylation and degradation pathway is a general feature in tumors across a wide range of tissues, as evidenced by data from The Cancer Genome Atlas, as well as in the noncancerous proliferative disease psoriasis. Expand
Amyloid precursor protein is a primary androgen target gene that promotes prostate cancer growth.
TLDR
The present study reveals a novel APP-mediated pathway responsible for the androgen-dependent growth of prostate cancer and indicates that APP could be a potential molecular target for the diagnosis and treatment of Prostate cancer. Expand
Dysregulation of spliceosome gene expression in advanced prostate cancer by RNA-binding protein PSF
TLDR
It is revealed that various spliceosome genes are aberrantly induced by RNA-binding protein PSF, leading to enhancement of the splicing activities for AR expression, suggesting a role of RNA- binding protein for AR activation for prostate cancer progression. Expand
Androgen-induced Long Noncoding RNA (lncRNA) SOCS2-AS1 Promotes Cell Growth and Inhibits Apoptosis in Prostate Cancer Cells*
TLDR
It is demonstrated that SOCS2-AS1 plays an important role in the development of castration-resistant prostate cancer by repressing apoptosis by modulating the epigenetic control for AR target genes including TNFSF10. Expand
miR-148a is an androgen-responsive microRNA that promotes LNCaP prostate cell growth by repressing its target CAND1 expression
TLDR
The study indicates the potential contribution of miR-148a to the growth of human prostate cancer and identifies androgen-responsive miRNAs by the short RNA sequencing analysis in LNCaP prostate cancer cells. Expand
Prostate cancer-associated lncRNAs.
TLDR
This review sheds light on the history and future perspective of several key lncRNAs identified as new players that contribute to the pathophysiology of the disease, which is primarily regulated by androgen and its cognate receptor. Expand
Association of USP10 with G3BP2 Inhibits p53 Signaling and Contributes to Poor Outcome in Prostate Cancer
TLDR
The oncogenic role of USP10 is elucidated through an increase in G3BP2 protein that inhibits p53 activity, in addition to the promotion of AR signaling, which highlights an importantOncogenic aspect of USp10 through its modulation of the p53–G3 BP2 complex and AR signaling in prostate cancer. Expand
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