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- Publications
- Influence
Feasibility of microneedles for percutaneous absorption of insulin.
- Y. Ito, E. Hagiwara, Atsushi Saeki, N. Sugioka, K. Takada
- Chemistry, Medicine
- European journal of pharmaceutical sciences…
- 1 September 2006
Insulin loaded microneedles were prepared using dextrin as the base for the percutaneous administration of insulin. Under room temperature, insulin solution was added to high concentration of dextrin… Expand
Enhanced intestinal absorption of vancomycin with Labrasol and D-alpha-tocopheryl PEG 1000 succinate in rats.
- Y. V. R. Prasad, S. Puthli, +4 authors K. Takada
- Chemistry, Medicine
- International journal of pharmaceutics
- 2 January 2003
Vancomycin hydrochloride (VCM) is a glycopeptide antibiotic used for the treatment of infections caused by methicillin-resistant staphylococci. It is water soluble, having a high molecular weight,… Expand
Oral solid gentamicin preparation using emulsifier and adsorbent.
- Y. Ito, Tomohiro Kusawake, M. Ishida, R. Tawa, N. Shibata, K. Takada
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 20 June 2005
Oral gentamicin (GM) therapy has been challenged by formulating GM in oral solid preparation. GM was dispersed with a surfactant used for the self-microemulsifying drug delivery system (SMEDDS),… Expand
In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer.
- Y. V. Rama Prasad, Takashi Minamimoto, +4 authors K. Takada
- Medicine
- International journal of pharmaceutics
- 1 March 2004
Oral absorption of low molecular weight heparin (LMWH) is limited by its molecular size and negative charge. Development of its oral formulations would allow outpatient treatment with LMWH and… Expand
Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats
- K. Fukushima, A. Ise, +4 authors K. Takada
- Medicine
- Pharmaceutical Research
- 2010
ABSTRACTPurposeFeasibility study of two-layered dissolving microneedles for percutaneous delivery of peptide/proteins using recombinant human growth hormone (rhGH) and desmopressin… Expand
Liquid filled nanoparticles as a drug delivery tool for protein therapeutics.
- N. Venkatesan, Junichiro Yoshimitsu, Y. Ito, N. Shibata, K. Takada
- Materials Science, Medicine
- Biomaterials
- 1 December 2005
In the present study, an attempt was made to study the feasibility of nanoparticulate adsorbents in the presence of an absorption enhancer, as a drug delivery tool for the administration of… Expand
Gastro-intestinal patch system for the delivery of erythropoietin.
- N. Venkatesan, K. Uchino, K. Amagase, Y. Ito, N. Shibata, K. Takada
- Chemistry, Medicine
- Journal of controlled release : official journal…
- 10 March 2006
The absorption of erythropoietin (EPO) from rat small intestine was studied using gastro-intestinal patches (GI-PS) in the presence of absorption enhancers. Surfactants such as a saturated… Expand
Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.
- Y. Ito, Hiroshi Murano, N. Hamasaki, K. Fukushima, K. Takada
- Chemistry, Medicine
- International journal of pharmaceutics
- 4 April 2011
Two-layered dissolving microneedles of which acral portion contained leuprolide acetate (LA) as solid dispersion were prepared with sodium chondroitin sulfate as the base and the systemic absorption… Expand
Pharmacokinetics of mycophenolate mofetil, a new immunosuppressant, in rats.
- N. Sugioka, H. Koyama, T. Ohta, H. Kishimoto, T. Yasumura, K. Takada
- Chemistry, Medicine
- Journal of pharmaceutical sciences
- 1 March 1996
Mycophenolate mofetil (MPM), a new immunosuppressant, is the morpholinoethyl ester of mycophenolic acid (MPA). The distribution in blood and pharmacokinetics of MPA after administration of MPM were… Expand
Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers.
- M. Kageyama, K. Fukushima, +7 authors K. Takada
- Biology, Medicine
- Biological & pharmaceutical bulletin
- 1 April 2006
P-Glycoprotein (Pgp) locates in several tissues in the living body and acts as an efflux pump for many drugs. In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a… Expand