K. Takada

Publications258
h-index38
Citations5,041
Highly Influential Citations137
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Feasibility of microneedles for percutaneous absorption of insulin.
Insulin loaded microneedles were prepared using dextrin as the base for the percutaneous administration of insulin. Under room temperature, insulin solution was added to high concentration of dextrin… Expand
  • 180
  • 6
Enhanced intestinal absorption of vancomycin with Labrasol and D-alpha-tocopheryl PEG 1000 succinate in rats.
Vancomycin hydrochloride (VCM) is a glycopeptide antibiotic used for the treatment of infections caused by methicillin-resistant staphylococci. It is water soluble, having a high molecular weight,… Expand
  • 100
  • 6
Oral solid gentamicin preparation using emulsifier and adsorbent.
Oral gentamicin (GM) therapy has been challenged by formulating GM in oral solid preparation. GM was dispersed with a surfactant used for the self-microemulsifying drug delivery system (SMEDDS),… Expand
  • 123
  • 6
In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer.
Oral absorption of low molecular weight heparin (LMWH) is limited by its molecular size and negative charge. Development of its oral formulations would allow outpatient treatment with LMWH and… Expand
  • 56
  • 6
Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats
ABSTRACTPurposeFeasibility study of two-layered dissolving microneedles for percutaneous delivery of peptide/proteins using recombinant human growth hormone (rhGH) and desmopressin… Expand
  • 114
  • 5
Liquid filled nanoparticles as a drug delivery tool for protein therapeutics.
In the present study, an attempt was made to study the feasibility of nanoparticulate adsorbents in the presence of an absorption enhancer, as a drug delivery tool for the administration of… Expand
  • 195
  • 4
Gastro-intestinal patch system for the delivery of erythropoietin.
The absorption of erythropoietin (EPO) from rat small intestine was studied using gastro-intestinal patches (GI-PS) in the presence of absorption enhancers. Surfactants such as a saturated… Expand
  • 57
  • 4
Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.
Two-layered dissolving microneedles of which acral portion contained leuprolide acetate (LA) as solid dispersion were prepared with sodium chondroitin sulfate as the base and the systemic absorption… Expand
  • 37
  • 4
Pharmacokinetics of mycophenolate mofetil, a new immunosuppressant, in rats.
Mycophenolate mofetil (MPM), a new immunosuppressant, is the morpholinoethyl ester of mycophenolic acid (MPA). The distribution in blood and pharmacokinetics of MPA after administration of MPM were… Expand
  • 10
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Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers.
P-Glycoprotein (Pgp) locates in several tissues in the living body and acts as an efflux pump for many drugs. In this study, the usefulness of intravenous rhodamine 123 (Rho123) administration as a… Expand
  • 63
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