K. Takada

Publications263
h-index40
Citations5,503
Highly Influential Citations142
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Oral solid gentamicin preparation using emulsifier and adsorbent.
TLDR
The results suggest that an adsorbent system is useful as an oral solid delivery system of poorly absorbable drugs such as GM.
Feasibility of microneedles for percutaneous absorption of insulin.
TLDR
The usefulness of a self-dissolving microneedle for the percutaneous delivery of peptide/protein drugs like insulin is suggested and it is suggested that almost all of the formulated insulin was released within 1 h.
Enhanced intestinal absorption of vancomycin with Labrasol and D-alpha-tocopheryl PEG 1000 succinate in rats.
TLDR
The results of the study indicate that formulations containing Labrasol and TPGS improve intestinal absorption of hydrophilic macromolecular drug, VCM.
Two-Layered Dissolving Microneedles for Percutaneous Delivery of Peptide/Protein Drugs in Rats
TLDR
Results suggest that the two-layered dissolving microneedles are useful as an immediate-release transdermal DDS for peptide/protein drugs.
In situ intestinal absorption studies on low molecular weight heparin in rats using labrasol as absorption enhancer.
TLDR
Labrasol increased the intestinal absorption of LMWH, and jejunum was found to be the best site of absorption, and maintaining high drug concentration gradient across intestinal wall is important to obtain increased intestinal LMWH absorption.
Biopharmaceutical study of the hepato-biliary transport of drugs. I. Hepato-biliary transport of non-metabolizing organic anionic compounds in rat.
TLDR
The results suggest that these organic anions are transported from blood into bile at least two processes, namely hepatic uptake and biliary excretion, and that the hepatics uptake of these compounds is mainly due to the binding to the substances which exist in the liver cells.
Liquid filled nanoparticles as a drug delivery tool for protein therapeutics.
TLDR
In the present study, an attempt was made to study the feasibility of nanoparticulate adsorbents in the presence of an absorption enhancer, as a drug delivery tool for the administration of erythropoietin (EPO) to the small intestine, and Jejunum was found to be the best absorption site for the absorption of EPO from LFNPS.
Incidence of low bioavailability of leuprolide acetate after percutaneous administration to rats by dissolving microneedles.
TLDR
Two-layered dissolving microneedles of which acral portion contained leuprolide acetate (LA) as solid dispersion were prepared with sodium chondroitin sulfate as the base and the systemic absorption efficiency of LA was studied in rats after administration to their abdominal skin to find the cause of the low BA after percutaneous administration to rats.
Pharmacokinetics of mycophenolate mofetil, a new immunosuppressant, in rats.
TLDR
MPM, a new immunosuppressant, is the morpholinoethyl ester of mycophenolic acid, which existed in rat plasma as the highly bound form and disappeared from the systemic circulation with biexponential decay.
Relationship between excretion clearance of rhodamine 123 and P-glycoprotein (Pgp) expression induced by representative Pgp inducers.
TLDR
The observations suggest that the excretion clearances of Rho123 from blood circulation to the small intestine or to the bile after its intravenous administration are useful indicators to assess the Pgp function in the presence of Pgp inducers.
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