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Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.
Defensins comprise a potent class of membrane disruptive antimicrobial peptides (AMPs) with well-characterized broad spectrum and selective microbicidal effects. By using high-resolution synchrotronExpand
Arginine in α-Defensins
Background: Complete Lys-for-Arg substitutions in α-defensins Crp4 and RMAD4 affect microbicidal activities very differently. Results: The peptide-lipid phase behavior of Crp4, RMAD4, and associatedExpand
CXCL17 Is a Mucosal Chemokine Elevated in Idiopathic Pulmonary Fibrosis That Exhibits Broad Antimicrobial Activity
The mucosal immune network is a crucial barrier preventing pathogens from entering the body. The network of immune cells that mediates the defensive mechanisms in the mucosa is likely shaped byExpand
Synthesis, Structure, and Activities of an Oral Mucosal α-Defensin from Rhesus Macaque*
The oral cavity is an environment challenged by a large variety of pathogens. Consequently, the antimicrobial peptides expressed in that environment are interesting as they evolved to defend againstExpand
Tetrodotoxin and derivatives in several species of the gastropod Naticidae.
The organs of 195 specimens of 4 species of the gastropod Naticidae, collected from fish markets in Taiwan, were assayed for toxicity. The calf moon shell Natica vitellus contained weak toxicityExpand
Expression and purification of recombinant alpha-defensins and alpha-defensin precursors in Escherichia coli.
Recombinant expression of alpha-defensins can be obtained at efficient levels in Escherichia coli. Amplified alpha-defensin or pro-alpha-defensin coding cDNA sequences are cloned directionallyExpand
Biosynthesis and antimicrobial evaluation of backbone-cyclized α-defensins.
Defensins are antimicrobial peptides that are important in the innate immune defense of mammals. Upon stimulation by bacterial antigens, enteric α-defensins are secreted into the intestinal lumenExpand
Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa
Antibiotic-resistant bacterial pathogens threaten public health. Because many antibiotics target specific bacterial enzymes or reactions, corresponding genes may mutate under selection and lead toExpand
Hydrophobic Determinants of α-Defensin Bactericidal Activity
ABSTRACT Mammalian α-defensins are approximately 4- to 5-kDa broad-spectrum antimicrobial peptides and abundant granule constituents of neutrophils and small intestinal Paneth cells. The bactericidalExpand
Small-angle X-ray scattering studies of peptide-lipid interactions using the mouse paneth cell α-defensin cryptdin-4.
In the presence of specialized proteins or peptides, a biological membrane can spontaneously restructure itself to allow communication between the intracellular and the extracellular sides. ExamplesExpand