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An Oral Adsorbent, AST-120 Protects Against the Progression of Oxidative Stress by Reducing the Accumulation of Indoxyl Sulfate in the Systemic Circulation in Renal Failure
TLDR
It is proposed that AST-120 reduces IS concentrations in the blood that induces ROS production in endothelial cells, thereby inhibiting the subsequent occurrence of oxidative stress in the systemic circulation in renal failure.
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Pharmaceutical aspects of the recombinant human serum albumin dimer: structural characteristics, biological properties, and medical applications.
TLDR
The structural characteristics of recombinant albumin dimers produced by two methods, namely, chemical linkage with 1,6-bis(maleimido)hexane and genetically linked with an amino acid linker, and the physicochemical characteristics and biological properties of these preparations are summarized.
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Species Distribution of Candidemia and Their Susceptibility in a Single Japanese University Hospital: Prior Micafungin Use Affects the Appearance of Candida parapsilosis and Elevation of Micafungin…
TLDR
The effect of micafungin use on changes in the detected Candida species and low susceptibility and the risk of C. parapsilosis and the minimum inhibitory concentrations (MICs) and amount of antifungal prescriptions by department were investigated.
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Safety Evaluation of Hemoglobin-Albumin Cluster “HemoAct” as a Red Blood Cell Substitute
TLDR
Results indicate that HemoAct has sufficient preclinical safety as an alternative material for RBC transfusion and blood compatibility, hemodynamic response, and pharmacokinetic properties.
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Artificial oxygen carriers rescue placental hypoxia and improve fetal development in the rat pre-eclampsia model
TLDR
The present study is the first to demonstrate that artificial oxygen carriers successfully treat placental hypoxia, decrease maternal plasma levels of anti-angiogenic proteins and ameliorate fetal growth restriction in the pre-eclampsia rat model.
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Evaluation of carboxymethyl-beta-cyclodextrin with acid function: improvement of chemical stability, oral bioavailability and bitter taste of famotidine.
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Evaluation of a new type of nano-sized carbon monoxide donor on treating mice with experimentally induced colitis.
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Biomimetic carbon monoxide delivery based on hemoglobin vesicles ameliorates acute pancreatitis in mice via the regulation of macrophage and neutrophil activity
TLDR
The findings suggest that CO-HbV exerts superior anti-inflammatory effects against inflammatory disorders via the regulation of macrophage and neutrophil activity.
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Amino acids of importance for the antioxidant activity of human serum albumin as revealed by recombinant mutants and genetic variants.
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Nanoparticles of hydrophobized cluster dextrin as biodegradable drug carriers: solubilization and encapsulation of amphotericin B
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