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Connexin 32 of gap junctions contains two cytoplasmic calmodulin-binding domains.
TLDR
These studies identify two calmodulin-binding amino-acid sequences in connexin 32, and provide independent evidence thatCalmodulin may function as an intracellular ligand, regulating Ca2+-dependent intercellular communication across gap junctions. Expand
Ultrafast glutamate sensors resolve high-frequency release at Schaffer collateral synapses
TLDR
The development of an ultrafast genetically encoded glutamate sensor, iGluu, which allowed us to image glutamate clearance and synaptic depression during 100-Hz spike trains and identify the large conformational change after glutamate binding as the rate-limiting step. Expand
Mechanism of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N- diethylamino)phenyl]-1,3,5-triazin-4-yl]calmodulin interactions with smooth muscle myosin light chain kinase and derived peptides.
The mechanism of the interactions of 2-chloro-(epsilon-amino-Lys75)-[6-[4-(N,N-diethylamino)phenyl]- 1,3,5-triazin-4-yl]calmodulin (TA-calmodulin) with smooth muscle myosin light-chain kinase (MLCK)Expand
Ca2+-calmodulin inhibits Ca2+ release mediated by type-1, -2 and -3 inositol trisphosphate receptors.
TLDR
Ca(2+)-dependent inhibition of Ca(2+) release by calmodulin is mediated by a different site: it may reside on an accessory protein that associates with all three receptor subtypes, or Ca(1+)-calmodulin binding to a site lying between residues 1499 and 1649 of the type-1 receptor may inhibit Ca( 2+) release from any tetrameric receptor that includes a type- 1 subunit. Expand
Dual effect of ATP in the activation mechanism of brain Ca(2+)/calmodulin-dependent protein kinase II by Ca(2+)/calmodulin.
The activation mechanism of Ca(2+)/calmodulin-dependent protein kinase II (alphaCaMKII) is investigated by steady-state and stopped-flow fluorescence spectroscopies. Lys(75)-labeled TA-cal [Torok,Expand
Dual effect of ATP in the activation mechanism of brain Ca(2+)/calmodulin-dependent protein kinase II by Ca(2+)/calmodulin.
TLDR
Measurements show that calmodulin can assume at least two spectrally distinct conformations when bound to alphaCaMKII with estimated interprobe distances of 40 and 22-26 A.R.M., suggesting that while the binding of ATP induces a conformational change, Thr(286)-autophosphorylation is probably required for the transition of cal modulin into its most compact conformer. Expand
Flash photolysis studies of relaxation and cross-bridge detachment: higher sensitivity of tonic than phasic smooth muscle to MgADP
TLDR
The marked slowing by MgADP of the late phases of relaxation from rigor in femoral artery suggests that in tonic smooth muscle the nucleotide affects not only rigor bridges, but also additional state(s) of cooperatively cycling cross-bridges. Expand
The effects of MgADP on cross‐bridge kinetics: a laser flash photolysis study of guinea‐pig smooth muscle.
TLDR
The effects of MgADP on cross‐bridge kinetics were investigated using laser flash photolysis of caged ATP in guinea‐pig portal vein smooth muscle permeabilized with Staphylococcus aureus alpha‐toxin, finding that the high affinity reflects the properties of a state generated during the co‐operative reattachment cycle, rather than that of the rigor bridge. Expand
Oligomeric structure of alpha-calmodulin-dependent protein kinase II.
The subunit stoichiometry and symmetry of the neuronal alpha-calmodulin-dependent protein kinase II (alphaCaMKII) is investigated in this report to understand the structural basis of its regulationExpand
Expression and role of CR1 and CR2 on B and T lymphocytes under physiological and autoimmune conditions.
TLDR
The role of complement receptors CR1 (CD35) and CR2 (CD21) expressed on T and B cells may contribute to the initiation and maintenance of immune complex mediated autoimmune diseases such as systemic lupus erythematosus and rheumatoid arthritis. Expand
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