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The genome of the social amoeba Dictyostelium discoideum
The social amoebae are exceptional in their ability to alternate between unicellular and multicellular forms. Here we describe the genome of the best-studied member of this group, DictyosteliumExpand
Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity
Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found fiveExpand
Genome-wide search for novel human uORFs and N-terminal protein extensions using ribosomal footprinting.
So far, the annotation of translation initiation sites (TISs) has been based mostly upon bioinformatics rather than experimental evidence. We adapted ribosomal footprinting to puromycin-treated cellsExpand
Sequence and analysis of chromosome 2 of Dictyostelium discoideum
The genome of the lower eukaryote Dictyostelium discoideum comprises six chromosomes. Here we report the sequence of the largest, chromosome 2, which at 8 megabases (Mb) represents about 25% of theExpand
Comparative and functional genomics provide insights into the pathogenicity of dermatophytic fungi
BackgroundMillions of humans and animals suffer from superficial infections caused by a group of highly specialized filamentous fungi, the dermatophytes, which exclusively infect keratinized hostExpand
Fungal Alternative Splicing is Associated with Multicellular Complexity and Virulence: A Genome-Wide Multi-Species Study
Alternative splicing (AS) is a cellular process that increases a cell's coding capacity from a limited set of genes. Although AS is common in higher plants and animals, its prevalence in otherExpand
Insights into Sex Chromosome Evolution and Aging from the Genome of a Short-Lived Fish
The killifish Nothobranchius furzeri is the shortest-lived vertebrate that can be bred in the laboratory. Its rapid growth, early sexual maturation, fast aging, and arrested embryonic developmentExpand
The complex repeats of Dictyostelium discoideum.
In the course of determining the sequence of the Dictyostelium discoideum genome we have characterized in detail the quantity and nature of interspersed repetitive elements present in this species.Expand
High‐resolution mapping of the 8p23.1 beta‐defensin cluster reveals strictly concordant copy number variation of all genes
One unexpected feature of the human genome is the high structural variability across individuals. Frequently, large regions of the genome show structural polymorphisms and many vary in theirExpand
High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research
BackgroundThe annual fish Nothobranchius furzeri is the vertebrate with the shortest known life span in captivity. Fish of the GRZ strain live only three to four months under optimal laboratoryExpand