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Impact of obstructive sleep apnea on clinical and angiographic outcomes following percutaneous coronary intervention in patients with acute coronary syndrome.
- D. Yumino, Y. Tsurumi, Atsushi Takagi, K. Suzuki, H. Kasanuki
- The American journal of cardiology
There has been growing evidence associating obstructive sleep apnea (OSA) with cardiovascular pathogenesis. We hypothesized that OSA may affect outcomes after percutaneous coronary intervention (PCI)… Expand
Nonalcoholic fatty liver disease: US-based acoustic radiation force impulse elastography.
PURPOSE To investigate the clinical usefulness of ultrasonography-based acoustic radiation force impulse (ARFI) elastography (ie, ARFI sonoelastography) in patients with a diagnosis of nonalcoholic… Expand
A novel aspect of calpain activation
Calpain, a Ca2+‐dependent biomodulator, alters the properties of substrate proteins by cleaving them at a limited number of specific sites. Recent studies of the structure‐function relationship of… Expand
Transforming growth factor-beta activation of phosphatidylinositol 3-kinase is independent of Smad2 and Smad3 and regulates fibroblast responses via p21-activated kinase-2.
Transforming growth factor-beta (TGF-beta) stimulates cellular proliferation and transformation to a myofibroblast phenotype in vivo and in a subset of fibroblast cell lines. As the Smad pathway is… Expand
Antimicrobial Cathelicidin Peptide LL-37 Inhibits the LPS/ATP-Induced Pyroptosis of Macrophages by Dual Mechanism
Pyroptosis is a caspase-1 dependent cell death, associated with proinflammatory cytokine production, and is considered to play a crucial role in sepsis. Pyroptosis is induced by the two distinct… Expand
Transforming growth factor beta signaling via Ras in mesenchymal cells requires p21-activated kinase 2 for extracellular signal-regulated kinase-dependent transcriptional responses.
- K. Suzuki, M. Wilkes, N. Garamszegi, Maryanne Edens, E. Leof
- Medicine, Biology
- Cancer research
- 15 April 2007
Transforming growth factor beta (TGF-beta) signaling via Smad proteins occurs in various cell types. However, whereas the biological response to TGF-beta can be as distinct as growth promoting (i.e.,… Expand
Urinary bladder cancer: diffusion-weighted MR imaging--accuracy for diagnosing T stage and estimating histologic grade.
PURPOSE To prospectively evaluate the ability of diffusion-weighted (DW) magnetic resonance (MR) imaging to be used to determine the T stage of bladder cancer and to measure the correlation between… Expand
Efficacy of ezetimibe for the treatment of non‐alcoholic steatohepatitis: An open‐label, pilot study
- Masato Yoneda, K. Fujita, +13 authors A. Nakajima
- Hepatology research : the official journal of the…
- 14 April 2010
Aim: Non‐alcoholic steatohepatitis (NASH) is considered a hepatic manifestation of metabolic syndrome. However, effective drug therapy for NASH has not been established yet. In the present study, we… Expand
Foods and Nutrients in Relation to Bladder Cancer Risk: A Case-Control Study in Aichi Prefecture, Central Japan
To elucidate the role of diet in the etiology of bladder cancer, we conducted a case-control study from 1996 to 1999 in Aichi Prefecture, Central Japan. Cases were patients newly diagnosed with… Expand
A combination of TERT promoter mutation and MGMT methylation status predicts clinically relevant subgroups of newly diagnosed glioblastomas
- Hideyuki Arita, Kai Yamasaki, +50 authors K. Ichimura
- Medicine, Biology
- Acta neuropathologica communications
- 8 August 2016
The prognostic impact of TERT mutations has been controversial in IDH-wild tumors, particularly in glioblastomas (GBM). The controversy may be attributable to presence of potential confounding… Expand