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Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet
An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation and three flavonoids, capillarisin, cirsimaritin and rhamnocitrin were isolated from this extract. Expand
Renal targeting of arginine-vasopressin by modification with carbohydrates at the tyrosine side chain.
To extend the utility of a renal targeting system using carbohydrate derivatives, we investigated the in vivo tissue distribution in rats of arginine-vasopressin (AVP) derivatives modified at theExpand
1513-DMIa and 1513-DMIb, DNA methyltransferase inhibitors produced by Streptomyces sp. strain No. 1513.
Two new methyltransferase inhibitors were isolated from the culture filtrate of Streptomyces sp. strain No. 1513 and named 1513-DMIa and 1513-DMIb. 1513-DMIa and 1513-DMIb were distinguished inExpand
[D-Ala2]deltorphin II analogs with high affinity and selectivity for delta-opioid receptor.
Nine [D-Ala2]deltorphin II analogs having various aliphatic amino acids at positions 5 and 6 were synthesized to gain more information about the role of hydrophobic Val5,6 residues for the delta-opioid receptor selectivity and developed analogs with very high delta-affinity and selectivity over those of DL-II. Expand
Studies on analgesic oligopeptides. VII. Solid phase synthesis and biological properties of Tyr-D-Arg-Phe-beta Ala-NH2 and its fluorinated aromatic amino acid derivatives.
Tyr-D-Arg-Phe-beta Ala-NH2 and its six fluorinated analogs were synthesized and found that I was one of the most selective and potent mu-receptor agonists reported to date. Expand
Synthesis of peptides related to the C-terminus of B-peptide of ox co-fibrin (positions 16-21,15-21, and 13-21).
  • K. Suzuki
  • Chemistry, Medicine
  • Chemical & pharmaceutical bulletin
  • 25 August 1966
The synthesis of three peptides related to the C-terminus of B-peptide of ox cofibrin (positions 16∼21, 15∼21, and 13-21) is described. The biological activity of the peptides on isolated mouse ileumExpand
A prolyl endoproteinase that acts specifically on the extrinsic 18-kDa protein of photosystem II: purification and further characterization.
A comparison of the properties of the proteinase with those of a proline-specific endopeptidase from Flavobacterium suggests that these enzymes are quite different in terms of substrate specificity. Expand
Reversible changes in conformation of the 23-kDa protein of photosystem II and their relationship to the susceptibility of the protein to a proteinase from photosystem II membranes.
The results suggest that the scissile bond becomes reversibly exposed and susceptible to the proteinase in response to environmental changes, and the renaturation of the substrate was associated with the suppression of the susceptibility. Expand
Synthesis of carboxyl-terminal extension analogs of dermorphin and evaluation of their opioid receptor-binding and opioid activities.
Eight dermorphin (DM) analogs extended at the C-terminus, based on the sequence of prepro-DM deduced from the cDNA, were synthesized by a simultaneous solid-phase method in which a pair of peptidesExpand
Inhibitory effects of non-steroidal anti-inflammatory drugs on superoxide generation.
It is concluded that amfenac sodium and the other drugs are able to inhibit granulocyte O2- production by blocking the activation of NADPH-oxidase. Expand