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Effect of formulation variables on drug and polymer release from HPMC-based matrix tablets
Abstract The objective of this work was to assess the effect of two formulation variables, hydroxypropylmethylcellulose (HPMC)/lactose ratio and HPMC viscosity grade, on the release of a model drugExpand
Carbopol/pluronic phase change solutions for ophthalmic drug delivery.
  • H. R. Lin, K. Sung
  • Chemistry, Medicine
  • Journal of controlled release : official journal…
  • 3 December 2000
The results demonstrated that the carbopol/pluronic mixture can be used as an in situ gelling vehicle to enhance the ocular bioavailability. Expand
In situ gelling of alginate/pluronic solutions for ophthalmic delivery of pilocarpine.
Alginate/Pluronic mixture can be used as an in situ gelling vehicle to increase ocular bioavailability and retain pilocarpine better than the alginate or Pluronic solutions alone. Expand
Transdermal iontophoretic delivery of enoxacin from various liposome-encapsulated formulations.
The results of employing cathodal iontophoresis on negative charged liposomes suggested that the liposomal vesicles or phospholipids may carry enoxacin into deeper skin strata via the follicular route. Expand
Lipid nanoparticles with different oil/fatty ester ratios as carriers of buprenorphine and its prodrugs for injection.
The results indicate the feasibility of using lipid nanoparticles, especially SLNs and NLCs, as parenteral delivery systems for buprenorphine and its prodrugs. Expand
Transdermal delivery of nalbuphine and nalbuphine pivalate from hydrogels by passive diffusion and iontophoresis.
The iontophoretic permeation rates of NA were slightly decreased by the incorporation of polymers; however, the transdermal flux and membrane potential were independent of polymer concentrations for both NA and NAP, demonstrating that the polymer concentrations in the hydrogel formulations did not have significant effects on the iontophile permeation of NA. Expand
Ester prodrugs of morphine improve transdermal drug delivery: a mechanistic study
Two alkyl esters of morphine, morphine propionate (MPR) and morphine enanthate (MEN), were synthesized as potential prodrugs for transdermal delivery. The ester prodrugs could enhance transdermalExpand
Swelling of hydroxypropyl methylcellulose matrix tablets. 2. Mechanistic study of the influence of formulation variables on matrix performance and drug release.
The strong dependence of HPMC release on viscosity grade is explained on the basis of the concept of polymer disentanglement concentration and swelling inhomogeneity is proposed as being responsible for a higher apparent drug diffusivity and release rate. Expand
Mucoadhesive buccal disks for novel nalbuphine prodrug controlled delivery: effect of formulation variables on drug release and mucoadhesive performance.
Drug release rates for the disks were found to be a function of drug solubility, with higher drug release ratesFor disks loaded with more hydrophilic prodrugs and an increased amount of beta-cyclodextrin, and the CP/HPC ratio had no impact on the release of nalbuphine hydrochloride. Expand
Enhancement of transdermal apomorphine delivery with a diester prodrug strategy.
The results in the present work suggest the feasibility of diester prodrugs for the transdermal delivery of apomorphine and exhibited superior skin permeation compared to the parent drug when formulated into the emulsions. Expand