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A high observed substitution rate in the human mitochondrial DNA control region
The rate and pattern of sequence substitutions in the mitochondrial DNA (mtDNA) control region (CR) is of central importance to studies of human evolution and to forensic identity testing. Here, we… Expand
Reduction of Clofazimine by Mycobacterial Type 2 NADH:Quinone Oxidoreductase
- T. Yano, S. Kassovska-Bratinova, +5 authors H. Rubin
- Biology, Medicine
- The Journal of Biological Chemistry
- 30 December 2010
The mechanism of action of clofazimine (CFZ), an antimycobacterial drug with a long history, is not well understood. The present study describes a redox cycling pathway that involves the enzymatic… Expand
Invasive pneumococcal infections in children with sickle cell disease in the era of penicillin prophylaxis, antibiotic resistance, and 23-valent pneumococcal polysaccharide vaccination.
Rates and severity of pneumococcal infections in children with sickle cell disease were examined before licensure of pneumococcal-conjugated vaccine (PVC). Rates of peak invasive infection rates in… Expand
The interaction of a type A retroviral particle and class II human leukocyte antigen susceptibility genes in the pathogenesis of Graves' disease.
- J. Jaspan, K. Sullivan, +8 authors M. Bryer-Ash
- The Journal of clinical endocrinology and…
- 1 June 1996
We have previously reported that over 85% of patients with Graves' disease have detectable serum antibodies against a human intracisternal type A retroviral particle (HIAP), which are not present in… Expand
Establishing the identity of Anna Anderson Manahan
How outliers become superstars: what shadow coaches do.
- Kevin Sullivan
- The Journal of medical practice management : MPM
Physicians who score low on patient satisfaction surveys usually don't know what they're doing (or not doing) to cause below-average ratings. Too often, the temporary improvement gained from books… Expand