K. Sugio

Publications24
h-index12
Citations543
Highly Influential Citations9
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The role of glucocorticoid receptor and gene expression in the anti-inflammatory action of dexamethasone
GLUCOCORTICOIDS are potent anti-inflammatory agents, but the molecular mechanisms involved in this activity are not yet understood. The biological actions of various steroid hormones have been shown… Expand
The effect of CYP2C19 polymorphism on the safety, tolerability, and pharmacokinetics of tivantinib (ARQ 197): results from a phase I trial in advanced solid tumors.
BACKGROUND Tivantinib (formerly ARQ 197) is a selective inhibitor of c-Met mainly metabolized by CYP2C19. CYP2C19 is known for genetic polymorphisms, and ~20% of Asians are poor metabolizers (PMs),… Expand
Release of T‐kinin and bradykinin in carrageenin induced inflammation in the rat
T‐kinin T‐kininogen Bradykinin Inflammation Acute‐phase protein Carrageenin
Suppression by dexamethasone of vascular permeability responses induced with leukotrienes C and D in the rat skin.
The present experiment was designed to investigate whether glucocorticoids counteract proinflammatory action of leukotrienes C and D which were suggested to play an important role as mediators in the… Expand
Effects of luseogliflozin, a sodium–glucose co‐transporter 2 inhibitor, on 24‐h glucose variability assessed by continuous glucose monitoring in Japanese patients with type 2 diabetes mellitus: a…
The aim of the present study was to determine the effects of luseogliflozin on 24‐h glucose levels, assessed by continuous glucose monitoring, and on pharmacodynamic variables measured throughout the… Expand
The effect of CYP2C19 polymorphism on the tolerability of ARQ 197: Results from phase I trial in Japanese patients with metastatic solid tumors.
2516 Background: ARQ 197 is a selective, non-ATP competitive inhibitor of c-MET, a receptor tyrosine kinase implicated in tumor cell migration, invasion and proliferation. ARQ 197 is mainly… Expand
Inhibition of vascular permeability by cycloheximide in granulomatous inflammation.
Abstract The effect of cycloheximide on vascular permeability in proliferative inflammation was investigated by using 8-day-old granuloma pouch induced by carrageenin in rats. The vascular… Expand
Blockade by antiglucocorticoids, actinomycin D and cycloheximide of anti-inflammatory action of dexamethasone against bradykinin.
Comparative study between steroidal and nonsteroidal anti-inflammatory drugs on the mode of their actions on vascular permeability in rat carrageenin-air-pouch inflammation.
In an attempt to clarify mechanisms of anti-inflammatory actions of steroidal and nonsteroidal anti-inflammatory drugs with special reference to the possible role of E type prostaglandins in the… Expand
Vascular permeability responses and the role of prostaglandin E2 in an experimental allergic inflammation of air pouch type in rats
1 Rats were sensitized with azobenzene arsonate‐conjugated acetyl bovine serum albumin. An allergic inflammation was induced in the preformed air pouch in the dorsum of the sensitized rats by… Expand
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