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The signal transducer and activator of transcription 1alpha and interferon regulatory factor 1 are not essential for the induction of indoleamine 2,3-dioxygenase by lipopolysaccharide: involvement of
Indoleamine 2,3-dioxygenase (IDO) is induced by interferon (IFN)-gamma-mediated effects of the signal transducer and activator of transcription 1alpha (STAT1alpha) and interferon regulatory factorExpand
Sept8 controls the binding of vesicle‐associated membrane protein 2 to synaptophysin
Septins, a conserved family of GTP/GDP‐binding proteins, are present in organisms as diverse as yeast and mammals. We analyzed the distribution of five septins, Sept6, Sept7, Sept8, Sept9 and Sept11,Expand
Dysbindin-1, WAVE2 and Abi-1 form a complex that regulates dendritic spine formation
Genetic variations in dysbindin-1 (dystrobrevin-binding protein-1) are one of the most commonly reported variations associated with schizophrenia. As schizophrenia could be regarded as aExpand
The Role of the Tumor Necrosis Factor Receptor in 2,4,6-Trinitrobenzene Sulfonic Acid (TNBS)-Induced Colitis in Mice
We investigated the effect of TNBS administration using TNF-receptor knockout mice to elucidate the role of TNF receptors in chronic inflammation of the colon. Histologically, inflammatory cellExpand
Lack of tumor necrosis factor receptor type 1 inhibits liver fibrosis induced by carbon tetrachloride in mice.
Chronic liver injury causes liver regeneration, resulting in fibrosis. The proinflammatory cytokine tumor necrosis factor (TNF) is involved in the pathogenesis of many acute and chronic liverExpand
A phase advance of the light‐dark cycle stimulates production of BDNF, but not of other neurotrophins, in the adult rat cerebral cortex: association with the activation of CREB
Circadian variation in the expression of brain‐derived neurotrophic factor (BDNF) indicates that BDNF is involved in the regulation of diurnal rhythms in a variety of biological processes. However,Expand
Increases in tumor necrosis factor‐α following transient global cerebral ischemia do not contribute to neuron death in mouse hippocampus
The actions of tumor necrosis factor‐α (TNF‐α) produced by resident brain cells and bone marrow‐derived cells in brain following a transient global ischemia were evaluated. In wild‐type miceExpand
SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin‐signaling
SEPT9 is a member of the cytoskeleton‐related septin family, which is highly expressed in glia cells in neuronal tissues. Sequence alterations in SEPT9 are known to cause hereditary neuralgicExpand
Biochemical and morphological characterization of MAGI‐1 in neuronal tissue
The membrane‐associated guanylate kinase with inverted organization (MAGI) proteins consist of three members, MAGI‐1, MAGI‐2 (also known as S‐SCAM), and MAGI‐3. Although MAGI‐2 has been analyzed andExpand
Identification of a cell polarity-related protein, Lin-7B, as a binding partner for a Rho effector, Rhotekin, and their possible interaction in neurons
Rhotekin, an effector of Rho, is highly expressed in the brain but its function(s) in neurons is almost unknown. In an attempt to define the properties of Rhotekin in neuronal cells, we focused onExpand