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Model for signal sequence recognition from amino-acid sequence of 54K subunit of signal recognition particle
PROTEIN targeting to the endoplasmic reticulum in mammalian cells is catalysed by signal recognition particle (SRP)1,2. Cross-linking experiments have shown that the subunit of relative molecularExpand
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Alu elements as regulators of gene expression
Alu elements are the most abundant repetitive elements in the human genome; they emerged 65 million years ago from a 5′ to 3′ fusion of the 7SL RNA gene and amplified throughout the human genome byExpand
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Structure and assembly of the Alu domain of the mammalian signal recognition particle
The Alu domain of the mammalian signal recognition particle (SRP) comprises the heterodimer of proteins SRP9 and SRP14 bound to the 5′ and 3′ terminal sequences of SRP RNA. It retards the ribosomalExpand
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Characterization of APOBEC3G binding to 7SL RNA
Human APOBEC3 proteins are editing enzymes that can interfere with the replication of exogenous retroviruses such as human immunodeficiency virus (HIV), hepadnaviruses such as hepatitis B virusExpand
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Transcription termination and 3′ processing: the end is in site!
Max L. Birnstiel, Meinrad Busslinger, and Katharina Strub Institut fL~r Molekularbiologie II der Universitt Legon et al., 1979). While transcription termina- tion is dispensable, there is someExpand
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An E. coli ribonucleoprotein containing 4.5S RNA resembles mammalian signal recognition particle.
The signal recognition particle (SRP) plays a central role in directing the export of nascent proteins from the cytoplasm of mammalian cells. An SRP-dependent translocation machinery in bacteria hasExpand
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Alu RNP and Alu RNA regulate translation initiation in vitro
Alu elements are the most abundant repetitive elements in the human genome; they emerged from the signal recognition particle RNA gene and are composed of two related but distinct monomers (left andExpand
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Useful ‘junk’: Alu RNAs in the human transcriptome
Abstract.Alu elements are the most abundant repetitive elements in the human genome; they have amplified by retrotransposition to reach the present number of more than one million copies. AluExpand
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SRP Keeps Polypeptides Translocation-Competent by Slowing Translation to Match Limiting ER-Targeting Sites
SRP is essential for targeting nascent chains to the endoplasmic reticulum, and it delays nascent chain elongation in cell-free translation systems. However, the significance of this function hasExpand
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Binding sites of the 9- and 14-kilodalton heterodimeric protein subunit of the signal recognition particle (SRP) are contained exclusively in the Alu domain of SRP RNA and contain a sequence motif
The mammalian signal recognition particle (SRP) is a small cytoplasmic ribonucleoprotein required for the cotranslational targeting of secretory proteins to the endoplasmic reticulum membrane. TheExpand
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