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Impact of sleep debt on metabolic and endocrine function
Sleep debt has a harmful impact on carbohydrate metabolism and endocrine function similar to those seen in normal ageing and, therefore, sleep debt may increase the severity of age-related chronic disorders. Expand
Brief Communication: Sleep Curtailment in Healthy Young Men Is Associated with Decreased Leptin Levels, Elevated Ghrelin Levels, and Increased Hunger and Appetite
In this study, 12 young, healthy, normal-weight men exhibited reductions in the satiety hormone leptin, increases in the hunger hormone ghrelin, and increases in hunger after 2 nights of only 4 hours of sleep compared with after two nights of 10 hours ofSleep, suggesting inadequate sleep seems to influence the hormones that regulate satiety and hunger. Expand
The metabolic consequences of sleep deprivation.
The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk. Expand
Leptin levels are dependent on sleep duration: relationships with sympathovagal balance, carbohydrate regulation, cortisol, and thyrotropin.
- K. Spiegel, R. Leproult, M. L’Hermite-Balériaux, G. Copinschi, P. Penev, E. van Cauter
- The Journal of clinical endocrinology and…
- 1 November 2004
Sleep modulates a major component of the neuroendocrine control of appetite, and the effects of sleep duration on leptin were quantitatively associated with alterations of the cortisol and TSH profiles and were accompanied by an elevation of postbreakfast homeostasis model assessment values. Expand
Sleep loss: a novel risk factor for insulin resistance and Type 2 diabetes.
- K. Spiegel, K. Knutson, R. Leproult, E. Tasali, E. van Cauter
- Journal of applied physiology
- 1 November 2005
Chronic sleep loss, behavioral or sleep disorder related, may represent a novel risk factor for weight gain, insulin resistance, and Type 2 diabetes. Expand
Effects of poor and short sleep on glucose metabolism and obesity risk
The laboratory and epidemiologic evidence suggests how sleep loss, either behavioral or disease-related, and poor quality of sleep might promote the development of obesity and diabetes mellitus, and exacerbate existing endocrine conditions. Expand
Metabolic consequences of sleep and sleep loss.
The marked decrease in average sleep duration in the last 50 years coinciding with the increased prevalence of obesity, together with the observed adverse effects of recurrent partial sleep deprivation on metabolism and hormonal processes, may have important implications for public health. Expand
PHYSIOLOGY OF SLEEP (REVIEW)–Interactions between stress and sleep: from basic research to clinical situations
Abstract Acute stress is a fundamental adaptive response which enables an organism to cope with daily threatening environmental stimuli. If prolonged and uncontrollable, the stress response may… Expand
Impact of Sleep and Sleep Loss on Neuroendocrine and Metabolic Function
- E. van Cauter, U. Holmbäck, +7 authors K. Spiegel
- Hormone Research in Paediatrics
- 1 February 2007
Background: Sleep exerts important modulatory effects on neuroendocrine function and glucose regulation. During the past few decades, sleep curtailment has become a very common behavior in… Expand
Sleep as a Mediator of the Relationship between Socioeconomic Status and Health: A Hypothesis
- E. van Cauter, K. Spiegel
- Psychology, Medicine
- Annals of the New York Academy of Sciences
- 1 December 1999
Results indicate that sleep loss can increase the “allostatic load” and facilitate the development of chronic conditions, such as obesity, diabetes, and hypertension, which have an increased prevalence in low SES groups. Expand