• Publications
  • Influence
Differential regulation of midbrain dopaminergic neuron development by Wnt-1, Wnt-3a, and Wnt-5a
The Wnts are a family of glycoproteins that regulate cell proliferation, fate decisions, and differentiation. In our study, we examined the contribution of Wnts to the development of ventral midbrainExpand
  • 354
  • 21
Endocannabinoids regulate interneuron migration and morphogenesis by transactivating the TrkB receptor.
In utero exposure to Delta(9)-tetrahydrocannabinol (Delta(9)-THC), the active component from marijuana, induces cognitive deficits enduring into adulthood. Although changes in synaptic structure andExpand
  • 235
  • 16
  • PDF
Purified Wnt‐5a increases differentiation of midbrain dopaminergic cells and dishevelled phosphorylation
The Wnt family of lipoproteins regulates several aspects of the development of the nervous system. Recently, we reported that Wnt‐3a enhances the proliferation of midbrain dopaminergic precursors andExpand
  • 130
  • 10
Roles for miRNA-378/378* in adipocyte gene expression and lipogenesis.
In this study, we explored the roles of microRNAs in adipocyte differentiation and metabolism. We first knocked down Argonaute2 (Ago2), a key enzyme in the processing of micro-RNAs (miRNAs), toExpand
  • 195
  • 8
  • PDF
Brain‐derived neurotrophic factor controls functional differentiation and microcircuit formation of selectively isolated fast‐spiking GABAergic interneurons
GABAergic interneurons with high‐frequency firing, fast‐spiking (FS) cells, form synapses on perisomatic regions of principal cells in the neocortex and hippocampus to control the excitability ofExpand
  • 87
  • 6
Ventral midbrain glia express region-specific transcription factors and regulate dopaminergic neurogenesis through Wnt-5a secretion
Glial cells have been classically described as supporting cells for neurons. Recently, additional roles during neural development have begun to emerge. Here, we report that ventral midbrain glia,Expand
  • 108
  • 6
Microarray Analyses Support a Role for Nurr1 in Resistance to Oxidative Stress and Neuronal Differentiation in Neural Stem Cells
Nurr1 is an orphan nuclear receptor required for the development of midbrain dopaminergic neurons. To better understand the molecular consequences of Nurr1 expression, we compared the transcriptomesExpand
  • 40
  • 5
Persephin-Overexpressing Neural Stem Cells Regulate the Function of Nigral Dopaminergic Neurons and Prevent Their Degeneration in a Model of Parkinson's Disease
Persephin (PSP) is a neurotrophic factor of the GDNF family that has been found to promote the survival of multiple populations of neurons. In the present study we have examined: (1) the mechanism ofExpand
  • 81
  • 4
Wnt2 Regulates Progenitor Proliferation in the Developing Ventral Midbrain*
Wnts are secreted, lipidated proteins that regulate multiple aspects of brain development, including dopaminergic neuron development. In this study, we perform the first purification and signalingExpand
  • 66
  • 4
Endocannabinoid-Independent Retrograde Signaling at Inhibitory Synapses in Layer 2/3 of Neocortex: Involvement of Vesicular Glutamate Transporter 3
Recent studies implicate dendritic endocannabinoid release from subsynaptic dendrites and subsequent inhibition of neurotransmitter release from nerve terminals as a means of retrograde signaling inExpand
  • 95
  • 3
  • PDF