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Autophagy Activation in Hepatocellular Carcinoma Contributes to the Tolerance of Oxaliplatin via Reactive Oxygen Species Modulation
Targeting the autophagy pathway is a promising therapeutic strategy to enhance the effects of chemotherapy and improve clinical outcomes in HCC patients.
Margin-Infiltrating CD20+ B Cells Display an Atypical Memory Phenotype and Correlate with Favorable Prognosis in Hepatocellular Carcinoma
The profile of CD20+ B cells in situ is a new predictor of prognosis for patients with hepatocellular carcinoma and provides a novel target for an optimal immunotherapy against this fatal malignancy.
Macrophage-secreted IL-8 induces epithelial-mesenchymal transition in hepatocellular carcinoma cells by activating the JAK2/STAT3/Snail pathway.
It is found that macrophages that have infiltrated tumors may induce epithelial-mesenchymal transition of HCC cells via the IL-8 activated JAK2/STAT3/Snail signaling pathway and this may offer a potential target for developing new HCC therapies.
Tumor-associated macrophages modulate resistance to oxaliplatin via inducing autophagy in hepatocellular carcinoma
Targeting TAMs is a promising therapeutic strategy to enhance the effects of chemotherapy oxaliplatin in HCC patients through inducing autophagy to avoid apoptosis and co-implantation with macrophages in H CC xenografts weakens cytotoxic effect of oxali Platin.
Long non-coding RNA 00607 as a tumor suppressor by modulating NF-&kgr;B p65/p53 signaling axis in hepatocellular carcinoma
The findings of this study show that the TNF-α/IL-6-lncRNA 00607-NF-κB p65/p53 signaling axis represents a novel therapeutic avenue in cancer chemotherapy.
Prognostic significance and clinical relevance of Sprouty 2 protein expression in human hepatocellular carcinoma.
  • K. Song, Q. Gao, Jia Fan
  • Medicine, Biology
    Hepatobiliary & pancreatic diseases international…
  • 15 April 2012
B7-H3 is expressed in human hepatocellular carcinoma and is associated with tumor aggressiveness and postoperative recurrence
  • T. Sun, Q. Gao, Jia Fan
  • Biology, Medicine
    Cancer Immunology, Immunotherapy
  • 22 May 2012
The data suggest that B7-H3 was abundantly expressed in HCC and was associated with adverse clinicopathologic features and poor outcome, and represents an attractive target for diagnostic and therapeutic manipulation in human HCC.
Lamp2a is required for tumor growth and promotes tumor recurrence of hepatocellular carcinoma.
Impaired Lamp2a expression in HCC contributes to tumor cell viability and promotes tumor growth and recurrence, and Targeting chaperone-mediated autophagy through Lamp 2a may also imply a potentially novel treatment strategy for HCC.
ERBB3, IGF1R, and TGFBR2 expression correlate with PDGFR expression in glioblastoma and participate in PDGFR inhibitor resistance of glioblastoma cells.
It is suggested that ERBB3, IGF1R, and TGFBR2 were responsible for PDGFRi resistance and revealed that ER BB3 acted as potential prognostic marker and therapeutic target for GBM with high PDGFRA expression.