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Amyloid cascade hypothesis: Pathogenesis and therapeutic strategies in Alzheimer's disease

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Probing the outer mouth structure of the HERG channel with peptide toxin footprinting and molecular modeling.

A working model is proposed for the open conformation of the outer vestibule of the hERG channel, in which the S5-P linkers interact with the pore loops to influence ion flux through the pores.
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Study Antimicrobial Activity of Lemon (Citrus lemon L.) Peel Extract

The main objective of the study is extraction, identification of antimicrobial compounds and demonstration of antimicrobial activity of lemon (Citrus lemon L.) peel against bacteria. As microorganism…

Interactions Between Charged Residues in the Transmembrane Segments of the Voltage-sensing Domain in the hERG Channel

This study studies the effects of reversing S4’s positive charges on channel activation, and confirms that there is functional coupling between D456 and K525 and between D411 and K538.
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Homology Modeling and Docking Studies of TMPRSS2 with Experimentally Known Inhibitors Camostat Mesylate, Nafamostat and Bromhexine Hydrochloride to Control SARS-Coronavirus-2

Results revealed the inhibition mechanism of TMPRSS2 by known inhibitors Camostat mesylate, Nafamostat and Bromhexine hydrochloride in detail at the molecular level, which may be helpful to prevent the entry to SARS-Coronavirus 2 in human cell.
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Identification of Angiotensin Converting Enzyme Inhibitor: An In Silico Perspective

TACE-ligand complex ZINC48251687 could be used as starting point for the development of new non-peptidic inhibitor of tACE and for designing drug against cardiovascular and related renal diseases.
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Ecofriendly production of silver nanoparticles using Candida utilis and its mechanistic action against pathogenic microorganisms

Ecofriendly biosynthesis of extracellular silver nanoparticles was carried out using Candida utilis NCIM 3469 and synthesized AgNPs showed antibacterial activity against pathogenic organisms and could be applicable in the development of antibacterial water filters for treatment of water.
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Purification and characterization of novel organic solvent tolerant 98kDa alkaline protease from isolated Stenotrophomonas maltophilia strain SK.

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Structural analysis of membrane-bound hECE-1 dimer using molecular modeling techniques: insights into conformational changes and Aβ1–42 peptide binding

The explicit molecular dynamics simulation revealed that the hECE-1 dimer exhibits conformational restrains and controls total central cavity by regulating the degree of fluctuations in some residues for substrate/product entrance/exit sites and conformational rearrangements of interdomain linkers as well as helices close to the inner surface are responsible for increasing totalcentral cavity of h ECE- 1 dimer.
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Characterization of the algC Gene Expression Pattern in the Multidrug Resistant Acinetobacter baumannii AIIMS 7 and Correlation with Biofilm Development on Abiotic Surface

Detailed observation on differential expression pattern of algC having strong correlation with important biofilm stages, scanning electron-microscopic evidence of biofilm augmentation taken together with predictive enzyme functions via molecular dynamic (MD) simulation, proposes a new basis of A. baumannii AIIMS 7 biofilm development on inanimate surfaces.
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