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Leakage-resistant blood vessels in mice transgenically overexpressing angiopoietin-1.
Angiopoietin-1 (Ang1) and vascular endothelial growth factor (VEGF) are endothelial cell-specific growth factors. Direct comparison of transgenic mice overexpressing these factors in the skinExpand
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Vascular endothelial-cadherin is an important determinant of microvascular integrity in vivo.
In the present paper, we characterize an antibody, mAb BV13, directed to mouse vascular endothelial (VE)-cadherin, a major adhesive protein of interendothelial adherens junctions. When added toExpand
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Expression of the angiogenic factors vascular endothelial cell growth factor, acidic and basic fibroblast growth factor, tumor growth factor beta-1, platelet-derived endothelial cell growth factor,
Angiogenesis is a significant prognostic factor in breast cancer, but the factors that control angiogenesis in vivo are not well defined. Multiple angiogenic polypeptides are known, and we haveExpand
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Translational up-regulation of the EGFR by tumor hypoxia provides a nonmutational explanation for its overexpression in human cancer
Overexpression of the EGF receptor (EGFR) is a recurrent theme in human cancer and is thought to cause aggressive phenotypes and resistance to standard therapy. There has, thus, been a concertedExpand
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Silencing of epidermal growth factor receptor suppresses hypoxia-inducible factor-2-driven VHL-/- renal cancer.
Inactivating mutations in the von Hippel-Lindau (VHL) tumor suppressor gene are associated with clear cell renal cell carcinoma (VHL-/- RCC), the most frequent malignancy of the human kidney. The VHLExpand
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Cytoskeletal F-actin patterns quantitated with fluorescein isothiocyanate-phalloidin in normal and transformed cells.
Actin in cultured fibroblasts is organized into a complex set of fibers. Patterns of organization visualized with antibody to actin are similar but not identical to those visualized with fluoresceinExpand
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Radiation responses in air-, nitrous oxide-, and nitrogen-saturated mammalian cells.
Characteristics of cellular radiation chemistry were studied for mammalian cells saturated with air, nitrous oxide, or nitrogen in the absence or presence of an OH-radical scavenger, for both low-Expand
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Multiple acquired renal carcinoma tumor capabilities abolished upon silencing of ADAM17.
Malignancy is a manifestation of acquired defects in regulatory circuits that direct normal cell proliferation and homeostasis. Most of these circuits operate through cell autonomous pathways,Expand
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The role of catheter surface morphology and extractable cytotoxic material in tissue reactions to urethral catheters.
Batches of urethral catheters associated with stricture formation during clinical usage were found to be amongst those causing marked acute and chronic inflammation after subcutaneous implantation inExpand
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Freeze-fracture study of the intercellular junctions in bronchiolo-alveolar carcinoma (Clara cell type).
Two bronchiolo-alveolar carcinomas of Clara cell type have been studied by thin section and freeze-fracture techniques. Thin sections of the tumour cells showed junctional complexes (tight junctionsExpand
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