• Publications
  • Influence
Anabolic signaling deficits underlie amino acid resistance of wasting, aging muscle
The nature of the deficit underlying age‐related muscle wasting remains controversial. To test whether it could be due to a poor anabolic response to dietary amino acids, we measured the rates ofExpand
  • 949
  • 118
Age‐related differences in the dose–response relationship of muscle protein synthesis to resistance exercise in young and old men
We investigated how myofibrillar protein synthesis (MPS) and muscle anabolic signalling were affected by resistance exercise at 20–90% of 1 repetition maximum (1 RM) in two groups (25 each) ofExpand
  • 540
  • 51
Selective activation of AMPK‐PGC‐1α or PKB‐TSC2‐mTOR signaling can explain specific adaptive responses to endurance or resistance training‐like electrical muscle stimulation
Endurance training induces a partial fast‐to‐slow muscle phenotype transformation and mitochondrial biogenesis but no growth. In contrast, resistance training mainly stimulates muscle proteinExpand
  • 435
  • 48
  • PDF
Acute skeletal muscle wasting in critical illness.
IMPORTANCE Survivors of critical illness demonstrate skeletal muscle wasting with associated functional impairment. OBJECTIVE To perform a comprehensive prospective characterization of skeletalExpand
  • 804
  • 47
Myofibrillar muscle protein synthesis rates subsequent to a meal in response to increasing doses of whey protein at rest and after resistance exercise.
BACKGROUND The intake of whey, compared with casein and soy protein intakes, stimulates a greater acute response of muscle protein synthesis (MPS) to protein ingestion in rested and exercised muscle.Expand
  • 269
  • 27
  • PDF
Immobilization induces anabolic resistance in human myofibrillar protein synthesis with low and high dose amino acid infusion
We tested the hypothesis that increasing blood amino acid (AA) availability would counter the physical inactivity‐induced reduction in muscle protein synthesis. We determined how 14 days ofExpand
  • 328
  • 19
Human muscle protein synthesis and breakdown during and after exercise.
Skeletal muscle demonstrates extraordinary mutability in its responses to exercise of different modes, intensity, and duration, which must involve alterations of muscle protein turnover, both acutelyExpand
  • 205
  • 15
  • PDF
Myofibrillar and collagen protein synthesis in human skeletal muscle in young men after maximal shortening and lengthening contractions.
We aimed to determine whether there were differences in the extent and time course of skeletal muscle myofibrillar protein synthesis (MPS) and muscle collagen protein synthesis (CPS) in humanExpand
  • 225
  • 13
  • PDF
A validation of the application of D(2)O stable isotope tracer techniques for monitoring day-to-day changes in muscle protein subfraction synthesis in humans.
Quantification of muscle protein synthesis (MPS) remains a cornerstone for understanding the control of muscle mass. Traditional [(13)C]amino acid tracer methodologies necessitate sustained bed restExpand
  • 105
  • 13
  • PDF
Anabolic signaling and protein synthesis in human skeletal muscle after dynamic shortening or lengthening exercise.
We hypothesized a differential activation of the anabolic signaling proteins protein kinase B (PKB) and p70 S6 kinase (p70(S6K)) and subsequent differential stimulation of human muscle proteinExpand
  • 146
  • 9
  • PDF