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Direct Effects of KATP Channel Openers Pinacidil and Diazoxide on Oxidative Phosphorylation of Mitochondria in situ
KATP channel openers protect ischemic-reperfused myocardium by mimicking ischemic preconditioning, however, the protection mechanisms have not been fully clarified yet. Since the skinned fibersExpand
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Anthocyanins block ischemia-induced apoptosis in the perfused heart and support mitochondrial respiration potentially by reducing cytosolic cytochrome c.
Anthocynanins, found in fruits and vegetables, have a variety of protective properties, which have generally been attributed to their antioxidant capacity. However, antioxidants are generally strongExpand
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Anthocyanins as substrates for mitochondrial complex I – protective effect against heart ischemic injury
Anthocyanins, a subclass of flavonoids, are known to protect against myocardial ischemia; however, little is known about their direct, acute effects on mitochondria injured by the ischemic insult. InExpand
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Anthocyanins in cardioprotection: A path through mitochondria.
Constantly growing experimental data from in vitro, in vivo and epidemiological studies show the great potential of anthocyanin-containing fruit and berry extracts or pure individual anthocyanins asExpand
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Protecting the heart against ischemia/reperfusion-induced necrosis and apoptosis: the effect of anthocyanins.
BACKGROUND AND OBJECTIVE It is well known that cardiomyocyte apoptosis contributes to ischemic heart damage. There is also increasing evidence that the polyphenolic compounds of natural origin, suchExpand
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Anthocyanins: From plant pigments to health benefits at mitochondrial level
Abstract Anthocyanins are water-soluble pigments providing certain color for various plant parts, especially in edible berries. Earlier these compounds were only known as natural food colorants, theExpand
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Protective effects of anthocyanins against brain ischemic damage
Anthocyanins are considered as bioactive components of plant-based diets that provide protection against ischemic cardiovascular pathologies by mechanisms dependent on their antioxidant and reductiveExpand
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Comparison of Effects of Metformin, Phenformin, and Inhibitors of Mitochondrial Complex I on Mitochondrial Permeability Transition and Ischemic Brain Injury
Damage to cerebral mitochondria, particularly opening of mitochondrial permeability transition pore (MPTP), is a key mechanism of ischemic brain injury, therefore, modulation of MPTP may be aExpand