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Study of an RNA helicase implicates small RNA-noncoding RNA interactions in programmed DNA elimination in Tetrahymena.
It is demonstrated that Twi1p interacts with noncoding transcripts derived from parental and developing macronuclei and this interaction is greatly reduced in the absence of Ema1p, and it is proposed that Ema 1p functions in DNA elimination by stimulating base-pairing interactions between scnRNAs and nonc coding transcripts in both parents and developing new macron nuclei.
Robust method for proteome analysis by MS/MS using an entire translated genome: demonstration on the ciliome of Tetrahymena thermophila.
To improve the utility of increasingly large numbers of available unannotated and initially poorly annotated genomic sequences for proteome analysis, we demonstrate that effective protein
Phosphorylation Motifs Regulating the Stability and Function of Myocyte Enhancer Factor 2A*
Several novel aspects of MEF2 regulation are identified that may prove important in the control of gene expression in neuronal and muscle cells and involve an evolutionarily conserved KSP motif.
Identification of secreted proteins during skeletal muscle development.
A putative network of proteins involving matrix metalloproteinase 2, SPARC, and cystatin C that all interact with TGFbeta signaling has been postulated to contribute toward a functional role in the myogenic differentiation program.
Fragmentations of protonated arginine, lysine and their methylated derivatives: concomitant losses of carbon monoxide or carbon dioxide and an amine.
Results of density functional theory calculations on Protonated arginine and protonated N(alpha),N(alpha)-dimethylarginine reveal that, in such concomitant eliminations, the dissociating complex is vibrationally hot and the intermediate ion formed by losing CO or CO(2) can immediately dissociate to eliminate the amine.
Protein Kinase A Represses Skeletal Myogenesis by Targeting Myocyte Enhancer Factor 2D
MEF2D is identified as a primary target of PKA signaling in myoblasts that leads to inhibition of the skeletal muscle differentiation program.
Proteomic Analysis of Brassica Stigmatic Proteins Following the Self-incompatibility Reaction Reveals a Role for Microtubule Dynamics During Pollen Responses*
56 differential protein spots with 19 unique candidate proteins whose abundance is down-regulated following self-incompatible pollinations are identified, predicted to function in various pathways including biosynthetic pathways, signaling, cytoskeletal organization, and exocytosis.
Gas-Phase Fragmentation Reactions of Protonated Aromatic Amino Acids: Concomitant and Consecutive Neutral Eliminations and Radical Cation Formations
Gas-phase dissociation reactions of protonated amino acidsphenylalanine, tyrosine, tryptophan, and histidineare rich and diverse. Considerable similarities exist among the four amino acids, but there
Elucidation of fragmentation mechanisms of protonated Peptide ions and their products: a case study on glycylglycylglycine using density functional theory and threshold collision-induced dissociation.
The activation barrier measured for the fragmentation of protonated triglycine to the b(2) ion and glycine is in good agreement with a calculated barrier at the B3LYP/6-31++G(d,p) level of theory reported earlier.
Silver ion binding energies of amino acids: Use of theory to assess the validity of experimental silver ion basicities obtained from the kinetic method
The complexes of silver ion, Ag+, with the twenty naturally occurring amino acids have been calculated using hybrid density functional theory at the B3LYP/DZVP level. For all of these silver