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Vimentin is secreted by activated macrophages
Vimentin is a widely expressed intermediate filament protein thought to be involved mainly in structural processes, such as wound healing. We now demonstrate that activated human macrophages secreteExpand
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Identification and characterization of Hoxa9 binding sites in hematopoietic cells.
The clustered homeobox proteins play crucial roles in development, hematopoiesis, and leukemia, yet the targets they regulate and their mechanisms of action are poorly understood. Here, we identifiedExpand
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The PAF complex synergizes with MLL fusion proteins at HOX loci to promote leukemogenesis.
MLL is involved in chromosomal rearrangements that generate fusion proteins with deregulated transcriptional activity. The mechanisms of MLL fusion protein-mediated transcriptional activation areExpand
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HOX proteins and leukemia.
HOX and three amino acid loop extension (TALE) proteins cooperate to induce transformation in mouse leukemia models, and are dysregulated in a variety of human leukemias. Despite decades of research,Expand
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The DEK Nuclear Autoantigen Is a Secreted Chemotactic Factor
ABSTRACT The nuclear DNA-binding protein DEK is an autoantigen that has been implicated in the regulation of transcription, chromatin architecture, and mRNA processing. We demonstrate here that DEKExpand
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Persistence of leukemia-initiating cells in a conditional knockin model of an imatinib-responsive myeloproliferative disorder.
Despite remarkable responses to the tyrosine kinase inhibitor imatinib, CML patients are rarely cured by this therapy perhaps due to imatinib refractoriness of leukemia-initiating cells (LICs).Expand
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p300/CBP-associated Factor Drives DEK into Interchromatin Granule Clusters*
DEK is a mammalian protein that has been implicated in the pathogenesis of autoimmune diseases and cancer, including acute myeloid leukemia, melanoma, glioblastoma, hepatocellular carcinoma, andExpand
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Minireview: DEK and gene regulation, oncogenesis and AIDS.
A brief review summarizing the relationships that exist between the DEK protein and gene regulation, oncogenesis and AIDS.
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DEK binding to class II MHC Y-box sequences is gene- and allele-specific
Using electrophoretic mobility shift assays, we examined sequence-specific binding of DEK, a potential autoantigen in juvenile rheumatoid arthritis, to conserved Y-box regulatory sequences in classExpand
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Antisense technology reveals the alpha2A adrenoceptor to be the subtype mediating the hypnotic response to the highly selective agonist, dexmedetomidine, in the locus coeruleus of the rat.
Alpha2 adrenergic agonists are used in the anesthetic management of the surgical patient for their sedative/hypnotic properties although the alpha2 adrenoceptor subtype responsible for theseExpand
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