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Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus.
Low solubility of tacrolimus in carrier matrix and subsequent poor in vivo bioavailability was overcome by constructing modified nanolipid carrier (MNLC) as a novel approach. The aim of this study… Expand
Formulation, antimalarial activity and biodistribution of oral lipid nanoemulsion of primaquine.
- K. Singh, Sharvani K. Vingkar
- Chemistry, Medicine
- International journal of pharmaceutics
- 22 January 2008
Primaquine (PQ) is one of the most widely used antimalarial and is the only available drug till date to combat relapsing form of malaria especially in case of Plasmodium vivax and Plasmodium ovale.… Expand
Targeting tacrolimus to deeper layers of skin with improved safety for treatment of atopic dermatitis.
Atopic dermatitis (AD) is chronically relapsing eczematous skin disorder having significant impact worldwide. Tacrolimus is the drug-of-choice which inhibits T-cell activation resulting in… Expand
Targeting tacrolimus to deeper layers of skin with improved safety for treatment of atopic dermatitis-Part II: in vivo assessment of dermatopharmacokinetics, biodistribution and efficacy.
The objective of present investigation was to study in vivo behavior of tacrolimus-loaded lipid-nanoparticles (T-LN) to understand its targeting potential for treatment of atopic-dermatitis-(AD).… Expand
Surface modified nevirapine nanosuspensions for viral reservoir targeting: In vitro and in vivo evaluation.
Most of the time HIV virus escape immunological burden exerted by antiretroviral drugs and develops resistance against therapy. For complete eradication of virus from body one has to use long term… Expand
Development and evaluation of colloidal modified nanolipid carrier: application to topical delivery of tacrolimus, Part II--in vivo assessment, drug targeting, efficacy, and safety in treatment for…
In atopic dermatitis (AD), topical anti-inflammatory therapy with skin barrier restoration to prevent repeated inflammatory episodes leads to long-term therapeutic success. Tacrolimus, although… Expand
Mangiferin: a promising anticancer bioactive.
- R. Khurana, Ranjot Kaur, Shikha Lohan, K. Singh, B. Singh
- Chemistry, Medicine
- Pharmaceutical patent analyst
- 18 April 2016
Of late, several biologically active antioxidants from natural products have been investigated by the researchers in order to combat the root cause of carcinogenesis, in other words, oxidative… Expand
In vitro protein adsorption studies on nevirapine nanosuspensions for HIV/AIDS chemotherapy.
- R. Shegokar, M. Jansch, K. Singh, R. Mueller
- Materials Science, Medicine
- Nanomedicine : nanotechnology, biology, and…
- 1 June 2011
UNLABELLED Nevirapine is a poorly water-soluble antiretroviral drug. Intravenous nevirapine nanosuspensions (NS) (457 ± 10 nm) were prepared by high-pressure homogenization. NS were surface modified… Expand
Development and evaluation of topical formulation containing solid lipid nanoparticles of vitamin A
The purpose of this research was to investigate novel particulate carrier system such as solid lipid nanoparticles (SLN) for topical application of vitamin A palmitate and to study its beneficial… Expand
A Comprehensive Review on Dry Eye Disease: Diagnosis, Medical Management, Recent Developments, and Future Challenges
- Suvarna P. Phadatare, M. Momin, Premanand A Nighojkar, Sonali S. Askarkar, K. Singh
- 28 January 2015
Dry eye syndrome (DES) or keratoconjunctivitis sicca (KCS) is a common disorder of the tear film caused by decreased tear production or increased evaporation and manifests with a wide variety of… Expand